Background: Unlike retinal arterial macroaneurysms, retinal venous macroaneurysms are rare. Retrospective studies have previously described venous macroaneurysms predominantly in association with branch retinal vein obstruction. Only 2 cases of isolated retinal venous macroaneurysm without venous occlusion have been described in the literature. The patient being described in this case report has the third isolated nonocclusive venous macroaneurysm to be reported.
Case: A healthy 43-year-old white woman presented for a routine eye examination with no history of visual disturbance other than long-standing amblyopia in the left eye (O.S.). An isolated retinal venous macroaneurysm was found on the inferior temporal retinal vein just beyond the optic disc margin. All other retinal findings were normal. One-month and 6-month followup examinations showed the macroaneurysm unchanged. The etiology of the retinal venous macroaneurysm in this case is unknown.
Conclusion: This patient has an isolated retinal venous macroaneurysm of unknown etiology. Based on the clinical profile of the patient, it is unlikely, although admittedly not impossible, for this to have resulted from a previous venous occlusive event. The identification and documentation of this extremely rare vascular phenomenon will help improve our understanding of its significance as well as any potential ocular sequela.
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http://dx.doi.org/10.1016/j.optm.2005.07.013 | DOI Listing |
Background: Mild cognitive impairment (MCI) is currently a clinical diagnosis characterized by decline in memory and daily cognitive function from baseline. Exploratory studies using optical coherence tomography angiography have reported alterations in the retinal capillary plexus vessel density and attenuation of the retinal nerve fiber layer, but these results appear to be mixed. We used ultra-widefield (UWF) imaging to evaluate retinal and choroidal vasculature and structure in individuals with mild cognitive impairment (MCI) compared to controls with normal cognition.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Background: Scanning laser ophthalmoscopy (SLO) visualizes two important markers of cognitive dysfunction in the retina: vascular changes and amyloid plaque (AP) deposition. The relationship between retinal arteriolar versus venular changes and perivascular amyloid deposition across the continuum of neurodegeneration is imperfectly understood. We investigate the retinal perivascular AP distribution in relationship to cognitive and neuroimaging measures in a cohort of cognitively normal and impaired individuals.
View Article and Find Full Text PDFFront Med (Lausanne)
December 2024
Department of Ophthalmology, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Proc Natl Acad Sci U S A
December 2024
Paris Cardiovascular Research Center, Université Paris Cité, Inserm U970, Paris F-75015, France.
The integrity of the blood-retina barrier (BRB) is crucial for phototransduction and vision, by tightly restricting transport of molecules between the blood and surrounding neuronal cells. Breakdown of the BRB leads to the development of retinal diseases. Here, we show that Netrin-1/Unc5b and Norrin/Lrp5 signaling establish a zonated endothelial cell gene expression program that controls BRB integrity.
View Article and Find Full Text PDFDiagnostics (Basel)
November 2024
Centre for Trusted Internet and Community, National University of Singapore, Singapore 119077, Singapore.
Diabetic retinopathy, hypertensive retinopathy, glaucoma, and contrast-related eye diseases are well-recognized conditions resulting from high blood pressure, rising blood glucose, and elevated eye pressure. Later-stage symptoms usually include patches of cotton wool, restricted veins in the optic nerve, and buildup of blood in the optic nerve. Severe consequences include damage of the visual nerve, and retinal artery obstruction, and possible blindness may result from these conditions.
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