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Simultaneous determination of capecitabine and its metabolites by HPLC and mass spectrometry for preclinical and clinical studies. | LitMetric

Simultaneous determination of capecitabine and its metabolites by HPLC and mass spectrometry for preclinical and clinical studies.

J Chromatogr B Analyt Technol Biomed Life Sci

Pharmacology and Drug Development Team, Cancer Research UK Centre, University of Edinburgh, Crewe Road, Edinburgh EH4 2XR, UK.

Published: November 2005

AI Article Synopsis

Article Abstract

A reverse-phase high-performance liquid chromatography method with electrospray ionization and detection by mass spectrometry is described for the simultaneous determination of capecitabine, its intermediate metabolites (DFCR, DFUR) and the active metabolite 5-fluorouracil in mouse plasma, liver and human xenograft tumours. The method was also cross-validated in human plasma and human tumour for clinical application. The method has greater sensitivity than previously published methods with an equivalent accuracy and precision. It uses less biological material (plasma, tissue) and should therefore be applicable to biopsies in patients treated with capecitabine.

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Source
http://dx.doi.org/10.1016/j.jchromb.2005.09.010DOI Listing

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