Follicle-stimulating hormone receptor gene mutations are not evident in Greek women with premature ovarian failure and poor responders.

Background/aims: This clinical and molecular study aimed to investigate the presence of follicle-stimulating hormone (FSH) receptor gene mutations in women with premature ovarian failure (POF) and poor responders to in vitro fertilization treatment.

Methods: DNA was extracted from blood samples for subsequent polymerase chain reaction (PCR). PCR was followed by restriction fragment length polymorphism and direct sequencing.

Results: No inactivating mutations reported so far were identified in exons 6, 7, and 10 in women with POF and poor responders.

Conclusion: FSH receptor gene mutations are not frequent in Greek patients with POF as is the case in the rest of the world except for cases with ovarian dysgenesis in Finland.