In 4 experiments, rats were initially trained with an A+ AXo discrimination in which Stimulus A by itself signaled the delivery of food, A+, whereas the simultaneous presentation of A and X was followed by nothing, AXo. In each experiment X was then paired with food prior to a test phase in which A and X were again presented for a discrimination. The discrimination was of the form A+ AXo in Experiments 1 and 2, whereas it was of the form X+ AXo for Experiments 3 and 4. In all 4 experiments the test discrimination was acquired more rapidly than a control discrimination. The results are interpreted in terms of the original A+ AXo discrimination resulting in the growth of an association between a representation of the entire AX compound and the effects of nonreinforcement.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
A dedicate sensorimotor circuit enables fine texture discrimination by active touch.
PLoS Genet
January 2023
School of Life Sciences, IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing, China.
Active touch facilitates environments exploration by voluntary, self-generated movements. However, the neural mechanisms underlying sensorimotor control for active touch are poorly understood. During foraging and feeding, Drosophila gather information on the properties of food (texture, hardness, taste) by constant probing with their proboscis.
View Article and Find Full Text PDFVisually Driven Neuropil Activity and Information Encoding in Mouse Primary Visual Cortex.
Front Neural Circuits
May 2018
Department of Neurology, Brigham and Women's HospitalBoston, MA, United States.
Cortical neuropil modulations recorded by calcium imaging reflect the activity of large aggregates of axo-dendritic processes and synaptic compartments from a large number of neurons. The organization of this activity impacts neuronal firing but is not well understood. Here we used 2-photon imaging with Oregon Green Bapta (OGB) and GCaMP6s to study neuropil visual responses to moving gratings in layer 2/3 of mouse area V1.
View Article and Find Full Text PDFFunctional P2X7 receptors at cultured hippocampal astrocytes but not neurons.
Naunyn Schmiedebergs Arch Pharmacol
October 2014
Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig, Haertelstrasse 16-18, 04107, Leipzig, Germany,
P2X7 receptors have been suggested to be located both on neurons and astrocytes of the central and peripheral nervous systems. In the present Ca(2+)-imaging and patch-clamp study, we reinvestigated these findings on mixed neuronal-astrocytic cell cultures prepared from embryonic or newborn rat hippocampi. We found in a Mg(2+)-free bath medium that the prototypic P2X7 receptor agonist dibenzoyl-adenosine triphosphate (Bz-ATP) increased the intracellular Ca(2+) concentration ([Ca(2+)]i) both in the neuronal cell bodies and in their axo-dendritic processes only to a very minor extent.
View Article and Find Full Text PDFDistinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells.
J Physiol
October 2011
Department of Anatomy, Pharmacology and Forensic Medicine and National Institute of Neuroscience-Italy, University of Turin, Italy.
Pyramidal cells express various GABA(A) receptor (GABA(A)R) subtypes, possibly to match inputs from functionally distinct interneurons targeting specific subcellular domains. Postsynaptic anchoring of GABA(A)Rs is ensured by a complex interplay between the scaffolding protein gephyrin, neuroligin-2 and collybistin. Direct interactions between these proteins and GABA(A)R subunits might contribute to synapse-specific distribution of GABA(A)R subtypes.
View Article and Find Full Text PDFAntidepressants differentially affect expression of complexin I and II RNA in rat hippocampus.
Psychopharmacology (Berl)
September 2005
Central Institute of Mental Health, P.O. Box 12 21 20, 68072, Mannheim, Germany.
Disturbance of synaptic transmission is currently viewed as an important pathophysiological mechanism and therapeutic target of mood disorders. Amongst other lines of evidence this theory is based on human post-mortem investigations showing differential expression of complexins. In order to discriminate between molecular correlates of the disease itself and effects of psychotropic drugs given to patients, we performed an animal trial using subchronic antidepressant treatment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!