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Addressing Diagnostic Challenges in Livedoid Vasculopathy: A Case Report on Interdisciplinary Management.
Cureus
October 2024
Internal Medicine, Veterans Affairs Caribbean Healthcare System, San Juan, PRI.
Livedoid vasculopathy (LV) is a rare vascular disorder characterized by excessive thrombosis of cutaneous vasculature, leading to dermal vessel occlusion, skin hypoxia, and ulceration. The nonspecific nature of its clinical manifestations often complicates diagnosis and inadequate oxygenation results in lesions that take longer to heal and are more susceptible to infections and complications. Despite its impact on patient quality of life, LV remains largely undocumented in the literature, making effective management challenging.
View Article and Find Full Text PDFMisdiagnosed for 14 Years: Adenosine Deaminase 2 (ADA2) Deficiency in a Teen Mimicking Polyarteritis Nodosa.
Clin Case Rep
November 2024
Department of Rheumatology, Autoimmune Disease Research Center, Beheshti Hospital Kashan University of Medical Sciences Kashan Iran.
The deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive disorder caused by loss of function mutations in the ADA2 gene (previously the CECR1 gene) on chromosome 22q11. The clinical spectrum of the disease is remarkably broad, and its presentations mimic features of polyarteritis nodosa, such as livedoid rash, hematological abnormalities (e.g.
View Article and Find Full Text PDFHyperbaric oxygen therapy enables pain reduction and healing in painful chronic wounds, including in calciphylaxis.
Ann Dermatol Venereol
December 2024
Department of Dermatology, Reims University Hospital, Reims, France.
Background: The effects of hyperbaric oxygen therapy (HBOT) on wound healing have been demonstrated mainly in diabetic foot ulcer.
Objectives: To study the efficacy and safety of HBOT in chronic painful wounds, excluding diabetic foot ulcers.
Methods: From 2008 to 2021, patients with chronic wounds showing no clinical improvement for more than 1 month, who were in pain despite the use of level 2 or 3 analgesics, and who had undergone HBOT sessions, were included in a monocentric retrospective study.
Clinical and patient reported treatment outcomes of livedoid vasculopathy: A systematic review.
Clin Exp Dermatol
September 2024
Department of Dermatology, Oregon Health & Science University, Portland, OR, USA.
Article Synopsis
- * A systematic review of 44 studies with 216 patients revealed Rivaroxaban as the most commonly used treatment, leading to complete or partial healing of ulcers in the majority of cases.
- * The review emphasizes the necessity for more research to discover better treatment options and to develop standardized care protocols for LV in future clinical studies.
Identification of Challenging Diagnostic Factors in Livedoid Vasculopathy: A Retrospective Study.
Clin Cosmet Investig Dermatol
August 2024
Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People's Republic of China.
Article Synopsis
- Livedoid vasculopathy is a rare skin condition that can be difficult to diagnose, leading to prolonged suffering and scarring for patients due to delays in correct identification.
- A study reviewed patient records at Peking Union Medical College Hospital to understand why initial misdiagnoses occurred and to improve diagnostic accuracy for this condition.
- Findings showed that most patients had alternative diagnoses, with the average time to correct diagnosis being over 4 years; common errors included misassessments by clinicians and inadequate follow-ups, emphasizing the need for greater awareness and timely skin biopsies before starting treatments.
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