Several lines of evidence suggest that genetic factors contribute to the vulnerability of drug abuse such as methamphetamine (MAP), and that dopamine-quinones produced by administration of MAP may be involved in the mechanism of MAP-related symptoms. The detoxification of quinones is catalyzed by a family of proteins designated as quinone oxidoreductases (NQOs). We analysed the polymorphisms of NQO1 and NQO2 genes to elucidate the association with genetic vulnerability to MAP abuse in Japan. The genotype and allele frequencies for the polymorphism (Pro187Ser) of the NQO1 gene did not differ between each subgroup of patients and controls. In contrast, the genotype frequency for the insertion/deletion (I/D) polymorphism in the promoter region of the NQO2 gene was a significant (p = 0.038) difference between patients with prolonged-type MAP psychosis and controls. This study suggests that the NQO2 gene polymorphism contributes to the aetiology of MAP-related psychosis in Japanese.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/13556210500123423 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
FRK exerts oncogenic effects by targeting NQO2 via exosomal miR-9-3p to regulate mitochondrial function.
FASEB J
December 2024
Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Article Synopsis
- The study investigates how Fyn-related kinase (FRK) influences tumor growth and metabolism in non-small cell lung cancer (NSCLC) through exosomes.
- Exosomes from FRK-knockout cells were shown to negatively impact NSCLC cell activities like proliferation and metabolism, highlighting the role of exosomal miR-9-3p.
- The research suggests that FRK promotes NSCLC progression by regulating mitochondrial function via miR-9-3p targeting the protein NQO2.
Melatonin Receptor Expression in Primary Uveal Melanoma.
Int J Mol Sci
August 2024
Department of Clinical Neuroscience, Division of Eye and Vision, Karolinska Institutet, 171 77 Stockholm, Sweden.
Article Synopsis
- - The study investigates melatonin receptor expression in primary Uveal melanoma (UM) and its potential link to cancer mortality and prognosis.
- - Analysis of 47 UM tissue samples revealed low levels of melatonin receptors (MTNR1A and MTNR1B), with MTNR1A expression being higher in patients who died from UM.
- - Although melatonin receptors were present and some associations with specific mutations were noted, the research found no significant differences in survival rates based on receptor expression levels.
Polymorphisms and Pharmacogenomics of : The Past and the Future.
Genes (Basel)
January 2024
Institute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), 88100 Catanzaro, Italy.
The flavoenzyme N-ribosyldihydronicotinamide (NRH):quinone oxidoreductase 2 (NQO2) catalyzes two-electron reductions of quinones. NQO2 contributes to the metabolism of biogenic and xenobiotic quinones, including a wide range of antitumor drugs, with both toxifying and detoxifying functions. Moreover, NQO2 activity can be inhibited by several compounds, including drugs and phytochemicals such as flavonoids.
View Article and Find Full Text PDFAutophagy and neuroprotection in astrocytes exposed to 6-hydroxydopamine is negatively regulated by NQO2: relevance to Parkinson's disease.
Sci Rep
December 2023
Laboratory of Neuroendocrine Endocrine and Germinal Differentiation and Communication (NorDiC), Univ Rouen Normandie, Inserm, NorDiC UMR 1239, 76000, Rouen, France.
Dopaminergic degeneration is a central feature of Parkinson's disease (PD), but glial dysfunction may accelerate or trigger neuronal death. In fact, astrocytes play a key role in the maintenance of the blood-brain barrier and detoxification. 6-hydroxydopamine (6OHDA) is used to induce PD in rodent models due to its specific toxicity to dopaminergic neurons, but its effect on astrocytes has been poorly investigated.
View Article and Find Full Text PDFDifferential haplotype expression in class I MHC genes during SARS-CoV-2 infection of human lung cell lines.
Front Immunol
March 2023
Bioinformatics Laboratory (LABINFO), National Laboratory of Scientific Computation (LNCC/MCTIC), Petrópolis, Brazil.
Introduction: Cell entry of SARS-CoV-2 causes genome-wide disruption of the transcriptional profiles of genes and biological pathways involved in the pathogenesis of COVID-19. Expression allelic imbalance is characterized by a deviation from the Mendelian expected 1:1 expression ratio and is an important source of allele-specific heterogeneity. Expression allelic imbalance can be measured by allele-specific expression analysis (ASE) across heterozygous informative expressed single nucleotide variants (eSNVs).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!