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Targeted Cx43 therapeutics reduce NLRP3 inflammasome activation in rat burn injury.
Burns
December 2024
Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Clinical Sciences Building, 11, Mandalay Road, 308232, Singapore; Skin Research Institute Singapore, Level 17, Clinical Sciences Building, 11, Mandalay Road, 308232, Singapore; National Skin Centre Singapore, 1 Mandalay Rd, 308205, Singapore. Electronic address:
Burns are dynamic injuries characterized by an initial zone of necrosis that progresses to compromise surrounding tissue. Acute inflammation and cell death are two main factors contributing to burn progression. These processes are modulated by Connexin43 (Cx43) hemichannels and gap junctions in burns and chronic wounds.
View Article and Find Full Text PDFArthroscopic Repair of Bursal-Sided Partial-Thickness Rotator Cuff Tears: Literature Review and Meta-analysis.
Am J Sports Med
January 2025
Service de chirurgie orthopédique et traumatologique, CHU de Toulouse, France.
Background: The surgical management of bursal-sided partial-thickness rotator cuff tendon tears is controversial. The 2 methods used are in situ repair (ISR), preserving the contingent of intact articular tendon fiber, or tear completion before repair (TCBR) according to the operating surgeon's usual technique. No study with sufficient power has demonstrated a superior technique.
View Article and Find Full Text PDFPartial-thickness rotator cuff tears (PTRCTs) are a common source of shoulder pathology, both in the aging population and in younger overhead athletes. Advanced imaging modalities used currently have led to increases in recognition, diagnosis, and treatment of these tears. The anatomy, five-layer histology, and relationship to the Ellman classification of PTRCTs have been well studied, with recent interest in radiographic predictors, such as the critical shoulder angle and acromial index.
View Article and Find Full Text PDFReepithelialization of partial thickness porcine burns treated with silver sulfadiazine, triple antibiotic or petrolatum.
Ann Burns Fire Disasters
December 2024
Department of Emergency Medicine, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.
Topical antibiotic application and occlusive dressings stand as the current standard of care for partial thickness burn (PTB) treatment. Silver sulfadiazine (SSD) is the most widely used topical antimicrobial agent for acute burn management worldwide. Despite its antimicrobial benefits, there is emerging evidence that SSD might delay wound reepithelialization.
View Article and Find Full Text PDFCould Fibrin Sealants (TISSEEL) Be Effective in the Management of Burn Injuries? A Histopathological Study in Rats.
Med Sci (Basel)
December 2024
Laboratory of Experimental Surgery and Surgical Research "N.S. Christeas", School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Burn injuries remain a major clinical problem worldwide, which require special management by experienced plastic surgeons. However, they cannot be available in every healthcare unit; consequently, there is a need for effective treatment options that could be utilized by a wide range of non-expert healthcare professionals. The aim of the present experimental study was to investigate the safety and efficacy of using a fibrin sealant (TISSEEL) compared to the conventional treatment with sulfadiazine on partial-thickness burn in a rat animal model.
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