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Development, implementation, and evaluation of an innovative clinical trial operations training program for Africa (ClinOps).
BMC Med Educ
January 2025
Center for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia.
Background: Africa's involvement in clinical trials remains very low. Although the crucial role of training initiatives in building clinical trial capacity in Africa has been documented, current efforts fall short as they lack alignment with local contexts. This study aimed to design, develop, implement, and evaluate an innovative clinical trial operations training program for Africa.
View Article and Find Full Text PDFPredatory journals: what can we do to protect their prey?
N Z Med J
January 2025
Editor-in-Chief, La Tunisie Médicale.
End tuberculosis strategy also requires initiation and integration of a national silicosis control program with the ongoing tuberculosis elimination activities: A review of the silicotuberculosis situation in India.
J Biol Methods
October 2024
Indian Council of Medical Research-National Institute of Occupational Health, Ahmedabad, Gujarat 380016, India.
Background: Earlier studies conducted by Indian researchers have demonstrated that the elimination of tuberculosis (TB) requires proactive control of silicosis, given India's significant burden of silicosis and its common comorbidity, pulmonary TB, also known as silicotuberculosis. The TB Control Indian Health Authority saw human immunodeficiency virus infection, diabetes, and malnutrition, among others, as important risk factors for case findings, but overlooked the significance of silicosis. Silicotuberculosis control is often confronted with challenges of detecting microorganisms, uncertain treatment outcomes, a higher likelihood of mono-drug and multi-drug resistance, and increased mortality due to treatment failure.
View Article and Find Full Text PDFComprehensive single-cell atlas of colorectal neuroendocrine tumors with liver metastases: unraveling tumor microenvironment heterogeneity between primary lesions and metastases.
Mol Cancer
January 2025
Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Background: Colorectal neuroendocrine tumors with liver metastases (CRNELM) are associated with a poorer prognosis compared to their nonmetastatic counterparts. A comprehensive understanding of the tumor microenvironment (TME) heterogeneity between primary lesions (PL) and liver metastases (LM) could provide crucial insights for enhancing clinical management strategies for these patients.
Methods: We utilized single-cell RNA sequencing to analyze fresh tissue samples from CRNELM patients, aiming to elucidate the variations in TME between PL and LM.
ERP correlates of agency processing in joint action.
Soc Cogn Affect Neurosci
January 2025
Department of Psychology, University of Essex, Colchester, United Kingdom.
In the Ouija board phenomenon, the lack of agency experienced by the players leads them to attribute the movement of the planchette to spirits. The aim of this study was to investigate the neural and cognitive mechanisms involved in generating the sense of agency in such a joint action context. Two players (a participant and a confederate) jointly moved a Ouija board style planchette containing a wireless mouse.
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