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http://dx.doi.org/10.1001/archinte.165.17.1943 | DOI Listing |
Mycobacteriophages are viruses that specifically infect bacteria of the Mycobacterium genus. A substantial collection of mycobacteriophages has been isolated and characterized, offering valuable insights into their diversity and evolution. This collection also holds significant potential for therapeutic applications, particularly as an alternative to antibiotics in combating drug-resistant bacterial strains.
View Article and Find Full Text PDFNat Commun
January 2025
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
While all native tRNAs undergo extensive post-transcriptional modifications as a mechanism to regulate gene expression, mapping these modifications remains challenging. The critical barrier is the difficulty of readthrough of modifications by reverse transcriptases (RTs). Here we use Induro-a new group-II intron-encoded RT-to map and quantify genome-wide tRNA modifications in Induro-tRNAseq.
View Article and Find Full Text PDFAbdom Radiol (NY)
January 2025
Department of Diagnostic and Interventional Radiology, Shanghai Eighth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: To investigative potential clinicopathological characteristics and imaging-related risk factors of clinically significant prostate cancer (csPCa) undercategorized in patients with negative or equivocal MRI.
Methods: This retrospective study included 581 patients with pathologically confirmed csPCa (Gleason score ≥ 3 + 4), including 108 undercategorized csPCa and 473 detected csPCa. All patients underwent multiparametric MRI (mpMRI).
Micromachines (Basel)
December 2024
Institute of Information Science, Beijing Jiaotong University, Beijing 100044, China.
Reconfigurable processor-based acceleration of deep convolutional neural network (DCNN) algorithms has emerged as a widely adopted technique, with particular attention on sparse neural network acceleration as an active research area. However, many computing devices that claim high computational power still struggle to execute neural network algorithms with optimal efficiency, low latency, and minimal power consumption. Consequently, there remains significant potential for further exploration into improving the efficiency, latency, and power consumption of neural network accelerators across diverse computational scenarios.
View Article and Find Full Text PDFBehav Res Methods
January 2025
Experimental Psychology, Helmholtz Institute, Utrecht, The Netherlands.
In this article, we discuss operationalizations and examples of experimental design in eye-tracking research. First, we distinguish direct operationalization for entities like saccades, which are closely aligned with their original concepts, and indirect operationalization for concepts not directly measurable, such as attention or mind-wandering. The latter relies on selecting a measurable proxy.
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