AI Article Synopsis
- The text discusses the development of rapamycin analogs that have been chemically modified at the C-40 position.
- These new compounds are being studied for their biological activities and potential benefits.
- A key focus is on creating versions that may be safer than rapamycin due to a shorter duration in the body (in vivo half-life).
Article Abstract
The synthesis and biological activities of rapamycin (I) analogs modified at the C-40 position are reported. Emphasis placed on compounds that potentially have an improved safety profile on account of their shorter in vivo half-life when compared with rapamycin.
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| http://dx.doi.org/10.1016/j.bmcl.2005.06.106 | DOI Listing |
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