Previously, with the administration of antidepressant drugs, it has been demonstrated that the rat model of clinical depression, known as the reduction of submissive behavior model (RSBM), has considerable validity. The present study is an attempt to extend the model to mice. Several antidepressant drugs as well as a number of non-antidepressant agents were administered to mice that had been identified as submissive in a behavioral testing situation. Imipramine, desipramine, amoxapine and fluoxetine, representing three different classes of antidepressant drugs, were each able to increase competitive behavior in submissive mice and to decrease the dominance level between dominant and submissive mice in the behavioral tests. The stimulant amphetamine also reduced submissive behavior while yohimbine (also a stimulant), and the antianxiety agent diazepam had no such effect. The neuroleptic drug thiothixen had antidepressant-like effect on submissive C57BL/6J mice behavior. We conclude that like the rat model of depression from which it was developed, the mouse model responds to various antidepressants as predicted and thus may serve as a potential model of clinical depression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pbb.2005.08.020 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Submissive behavior is affected by territory structure in a social fish.
Curr Zool
December 2024
School of Biological and Environmental Sciences, Liverpool John Moores University, 3 Byrom Street, Liverpool L3 3AF, UK.
Group living may engender conflict over food, reproduction, or other resources and individuals must be able to manage conflict for social groups to persist. Submission signals are an adaptation for establishing and maintaining social hierarchy position, allowing a subordinate individual to avoid protracted and costly aggressive interactions with dominant individuals. In the daffodil cichlid fish (), subordinates may use submission signals to resolve conflicts with dominant individuals and maintain their social status within the group.
View Article and Find Full Text PDFInter-call intervals, but not call durations, adhere to Menzerath's Law in the submissive vocal bouts of meerkats.
R Soc Open Sci
December 2024
Department of Evolutionary Biology and Environmental Studies, University of Zürich, Winterthurerstrasse 190, Zurich 8057, Switzerland.
Article Synopsis
- Researchers investigated Menzerath's Law in meerkats' vocalizations, which suggests a link between the number of calls in a sequence and their length.
- They analyzed 1,676 vocal bouts from 89 wild meerkats and found that, contrary to the law, longer calls occurred when there were more calls in a bout.
- However, they did observe a negative relationship between the size of a bout and the duration of inter-call intervals, indicating complex dynamics in meerkat communication.
Hippocampal area CA2 activity supports social investigation following an acute social stress.
Mol Psychiatry
November 2024
Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC, 27713, USA.
Neuronal activity in the hippocampus is critical for many types of memory acquisition and retrieval and influences an animal's response to stress. Moreover, the molecularly distinct principal neurons of hippocampal area CA2 are required for social recognition memory and aggression in mice. To interrogate the effects of stress on CA2-dependent behaviors, we chemogenetically manipulated neuronal activity in vivo during an acute, socially derived stressor and tested whether memory for the defeat was influenced.
View Article and Find Full Text PDFOrangutans and chimpanzees produce morphologically varied laugh facesin response to the age and sex of their social partners.
Sci Rep
November 2024
School of Psychology, Sport and Health Sciences, University of Portsmouth, Portsmouth, UK.
Laugh faces of humans play a key role in everyday social interactions as a pervasive tool of communication across contexts. Humans often vary the degree of mouth opening and teeth exposure when producing these facial expressions, which may depend on who their social partner is (e.g.
View Article and Find Full Text PDFForaging by predatory ants: A review.
Insect Sci
October 2024
Department of Entomology, Cornell University, Ithaca, NY, USA.
In this review, we show that predatory ants have a wide range of foraging behavior, something expected given their phylogenetic distance and the great variation in their colony size, life histories, and nesting habitats as well as prey diversity. Most ants are central-place foragers that detect prey using vision and olfaction. Ground-dwelling species can forage solitarily, the ancestral form, but generally recruit nestmates to retrieve large prey or a group of prey.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!