The use of olanzapine in the treatment of negative symptoms in Alzheimer's disease.

J Neuropsychiatry Clin Neurosci

Department of Behavioral Medicine and Psychiatry, West Virginia University, 930 Chestnut Ridge Rd., Morgantown, WV 26505-2854, USA.

Published: November 2005

AI Article Synopsis

  • The study tested olanzapine's effectiveness in treating negative symptoms in Alzheimer's patients over an 8-week period.
  • The participants were aged 50 and older and showed untreated neuropsychiatric issues related to their condition.
  • Results indicate that olanzapine could be a suitable treatment option for Alzheimer's patients dealing with these specific symptoms.

Article Abstract

The authors report findings from an 8-week, open-label trial conducted to evaluate efficacy of olanzapine in treating negative symptoms in Alzheimer's disease (AD). Subjects were AD patients age 50 and older who exhibited untreated neuropsychiatric symptoms. Findings suggest that a therapeutic profile for olanzapine may be appropriate for AD patients experiencing neuropsychiatric problems.

Download full-text PDF

Source
http://dx.doi.org/10.1176/jnp.17.3.423DOI Listing

Publication Analysis

Top Keywords

negative symptoms
8
symptoms alzheimer's
8
alzheimer's disease
8
olanzapine treatment
4
treatment negative
4
disease authors
4
authors report
4
report findings
4
findings 8-week
4
8-week open-label
4

Similar Publications

Longitudinal relationship between internet addiction and psychotic-like experiences among Chinese college students.

Compr Psychiatry

January 2025

Center for studies of Psychological Application, School of Psychology, South China Normal University, 510631 Guangzhou, China; School of Medicine, Indiana University, 46202 Indianapolis, USA. Electronic address:

Background: While previous cross-sectional studies have suggested a link between psychotic-like experiences (PLEs) and internet addiction (IA), longitudinal evidence remains scarce. This study aimed to explore the prospective relationship between IA and PLEs among college students.

Method: A total of 636 college students (80 % female) were assessed in November 2022 and again one year later.

View Article and Find Full Text PDF

Objective: The aim of the study is to assess the diagnostic accuracy of 4-dimensional computed tomography (4D-CT) scans for patients with primary hyperparathyroidism (pHPT) after negative or inconclusive Technetium-99m sestamibi single-photon emission computed tomography scan.

Methods: A literature search of several databases was conducted from inception to August 2023. Eligible studies reported adult patients (>18 years old) who underwent 4D-CT after negative or inconclusive sestamibi results.

View Article and Find Full Text PDF

Borderline personality disorder (BPD) has been described as a condition of intolerance of aloneness. This characteristic drives distinguishing criteria, such as frantic efforts to avoid abandonment. Both BPD and loneliness are linked with elevated mortality risk and multiple negative health outcomes.

View Article and Find Full Text PDF

Irritable Bowel Syndrome (IBS) patients and Somatization Symptom Disorder (SSD) patients experience somatization symptoms relative to their corresponding processes. IBS patients may also have a diagnosis of both IBS and SSD. Somatization symptoms cause significant psychological, emotional and social distress.

View Article and Find Full Text PDF

Infant neonatal intensive care unit (NICU) hospitalization increases maternal risk for post-traumatic stress disorder (PTSD) symptoms, which may negatively impact mother-child attachment and infant growth and development. Prior studies have documented positive associations between unmet parenting expectations and adverse maternal psychological outcomes, including post-NICU discharge. However, no studies have yet explored how unmet parenting expectations may be associated with maternal NICU-related PTSD symptoms.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!