Excessive sleepiness associated with narcolepsy lasts throughout the waking day. The authors conducted two randomized, double-blind studies to compare the efficacy of modafinil once-daily versus split doses in maintaining wakefulness throughout the day. Fifty-six patients received modafinil. The split-dose regimens were significantly more effective than the 200-mg once-daily regimen for sustaining wakefulness in the late afternoon/evening. All modafinil dosing regimens were well tolerated. In patients who experience excessive sleepiness in the late afternoon/evening, despite satisfactory treatment earlier in the day, a split dose of modafinil may promote wakefulness throughout the waking day.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1176/jnp.17.3.405 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Personal light treatment devices: a countermeasure to improve sleep, fatigue, and circadian misalignment in an operational setting.
Sleep Adv
December 2024
Operational Readiness and Health Directorate, Naval Health Research Center, San Diego, CA, USA.
Carefully timed light exposure is a promising countermeasure to overcome the negative sleep and circadian implications of shift work. However, many lighting interventions are static and applied at the group level (e.g.
View Article and Find Full Text PDFHigher physical activity levels are related to faecal microbiota diversity and composition in young adults.
Biol Sport
January 2025
PROFITH (PROmoting FITness and Health through Physical Activity) Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain.
Increasing physical activity (PA) is recognised as an efficacious approach for preventing and treating cardiometabolic diseases. Recently, the composition of microorganisms living within the gut has been proposed as an important appropriate target for treating these diseases. Whether PA is related to faecal microbiota diversity and composition in humans remains to be ascertained.
View Article and Find Full Text PDFTongue Ultrasonography in the Screening of Severe Obstructive Sleep Apnea Syndrome-Promising Potential for Overloaded Sleep Centers.
Diseases
December 2024
Department of Pneumology, Phthisiology and Functional Diagnostics, Slovak Medical University and Bratislava University Hospital, 82606 Bratislava, Slovakia.
Obstructive sleep apnea syndrome (OSAS) is a frequently underdiagnosed sleep disorder marked by recurrent episodes of apnea and/or hypopnea during sleep, primarily resulting from the partial or complete collapse of the upper airway. OSAS significantly affects patients' health and quality of life. Additionally, it is a recognized risk factor for inducing microsleep episodes during daily activities, particularly in occupations such as professional driving, where sustained attention is critical.
View Article and Find Full Text PDFCircadian rhythm mechanisms underlying convergent adaptation of unihemispheric slow-wave sleep in marine mammals.
Mol Biol Evol
December 2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, Guangdong 511458, China.
Marine mammals have evolved unihemispheric slow wave sleep (USWS), a unique state during which one cerebral hemisphere sleeps while the other remains awake, to mitigate the fundamental conflict between sleep and wakefulness. However, the underlying mechanisms remain largely unclear. Here, we use a comparative phylogenetic approach to analyze genes associated with light-dependent circadian mechanisms, aiming to reconstruct the evolution of the circadian rhythm pathway in mammals and to identify adaptively changed components likely to have contributed to the development of USWS.
View Article and Find Full Text PDFNon-apical plateau potentials and persistent firing induced by metabotropic cholinergic modulation in layer 2/3 pyramidal cells in the rat prefrontal cortex.
PLoS One
December 2024
Brain Signalling Laboratory, Section for Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Here we describe a type of depolarising plateau potentials (PPs; sustained depolarisations outlasting the stimuli) in layer 2/3 pyramidal cells (L2/3PC) in rat prefrontal cortex (PFC) slices, using whole-cell somatic recordings. To our knowledge, this PP type has not been described before. In particular, unlike previously described plateau potentials that originate in the large apical dendrite of L5 cortical pyramidal neurons, these L2/3PC PPs are generated independently of the apical dendrite.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!