AI Article Synopsis
- The study aimed to investigate the expression levels of urotensin II (U II) and G-protein coupled receptor 14 (GPR14) mRNA in human pheochromocytoma tissues compared to normal adrenal tissues.
- The researchers found that both U II and GPR14 mRNA levels were significantly lower in pheochromocytoma tissues than in normal adrenal cortex and medulla, indicating a potential impact on tumor behavior and hypertension.
- The results suggest that U II and GPR14 might play a role in the development of pheochromocytoma and its relation to hypertension regulation.
Article Abstract
Objective: To investigate the expression of urotensin II (U II) and G-protein coupled receptor 14 (GPR14) mRNA in human pheochromocytoma tissues.
Methods: Total RNA from normal adrenal and pheochromocytoma tissues was extracted. The reverse transcription-polymerase chain reaction method was used to evaluate the levels of U II and GPR14 mRNA expression in human pheochromocytoma tissues.
Results: There was no significant difference of U II and GPR14 mRNA expression between normal adrenal cortex and medulla. The expression of U II and GPR14 mRNA in pheochromocytoma was significantly lower than that in normal adrenal cortex and medulla (P < 0.05). The expression of GPR14 mRNA in adrenal pheochromocytomas was significantly lower than that of extra-adrenal pheochromocytomas (P < 0.05).
Conclusion: U II and GPR14 may play a role in the pathogenesis and hypertension regulating of pheochromocytoma.
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