A youngster with long-standing renal failure changed from peritoneal to hemodialysis, which worsened psychiatric symptoms and tics. TDM analysis of potential causes is presented.
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Rapid Metabolism Underlying Subtherapeutic Serum Levels of Atypical Antipsychotics Preceding Clozapine Treatment: A Retrospective Analysis of Real-World Data.
CNS Drugs
June 2024
Center for Psychopharmacology, Diakonhjemmet Hospital, Vinderen, PO Box 85, 0319, Oslo, Norway.
Introduction: Adequate antipsychotic treatment intensity is required before diagnosing resistant schizophrenia and initiating clozapine treatment. We aimed to investigate potential rapid drug metabolism underlying low dose-adjusted serum concentration (CD) of non-clozapine atypical antipsychotics preceding clozapine treatment.
Methods: Patients using non-clozapine, atypical antipsychotics (aripiprazole, risperidone, olanzapine, or quetiapine) within 1 year before starting clozapine were included in this study from a therapeutic drug monitoring service in Oslo, Norway, between 2005 and 2023.
[Therapeutic drug monitoring of risperidone and its active metabolite 9-hydroxyrisperidone in the treatment of schizophrenia].
Zh Nevrol Psikhiatr Im S S Korsakova
August 2019
Mental Health Research Center, Moscow, Russia.
Aim: To conduct a routine therapeutic drug monitoring (TDM) and analyze its results for the optimization of pharmacotherapy.
Material And Methods: Fifty-six inpatients (in total 68 samples) with various forms of schizophrenia were enrolled. High performance liquid chromatography with mass-spectrometric detection was used for quantitative determination of risperidone and 9-hydroxyrisperidone in the serum.
Determination of Chlorpromazine, Haloperidol, Levomepromazine, Olanzapine, Risperidone, and Sulpiride in Human Plasma by Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS).
Int J Anal Chem
September 2018
Department of Toxicology, Bab-El-Oued hospital, Avenue Mohamed Lamine Debaghine, 16009, Algiers, Algeria.
Background And Objective: In this study, turbo-ion spray as an interface of tandem mass spectrometry (MS/MS) was performed for sensitive and accurate quantification of chlorpromazine, haloperidol, levomepromazine, olanzapine, risperidone, and sulpiride in plasma samples.
Methods: Separation was performed by gradient reversed phase high-performance liquid chromatography using a mobile phase containing ammonium formiate 2 mM, pH 2.7, and acetonitrile flowing through a Restek PFP Propyl C18 analytical column (50 mm×2.
Accuracy of Clinician Assessments of Medication Status in the Emergency Setting: A Comparison of Clinician Assessment of Antipsychotic Usage and Plasma Level Determination.
J Clin Psychopharmacol
June 2017
From the *Department of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks; †Department of Psychiatry, The Hofstra Northwell School of Medicine, Hempstead; ‡New York State Psychiatric Institute, Columbia University College of Physicians & Surgeons, New York; and §Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY.
Purpose: The present study aimed to assess the level of agreement between clinicians' routine assessments of medication status and plasma levels of commonly prescribed antipsychotic medications in patients presenting to an emergency room with an exacerbation of psychosis.
Methods: We studied 105 patients presenting to an emergency room and admitted to an inpatient psychiatric unit with a diagnosis of schizophrenia, schizoaffective disorder, bipolar I disorder, or psychotic disorder not otherwise specified and a prior outpatient medication regimen including risperidone, olanzapine, quetiapine, aripiprazole, or paliperidone. Plasma levels of antipsychotics were drawn and sent to a specialty laboratory for testing.
Risperidone ameliorates post-traumatic stress disorder-like symptoms in modified stress re-stress model.
Neuropharmacology
December 2013
Department of Zoology, Faculty of Science, Banaras Hindu University, Varanasi 221005, India.
The management for post-traumatic stress disorder (PTSD) involves chronic administration of drugs. We have modified the stress re-stress (SRS) model to study the effect of chronic administration of risperidone (RIS) after induction of PTSD in rats. On day-1 (D-1) rats underwent training session for elevated-plus maze (EPM) test.
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