AI Article Synopsis
- The study aimed to investigate changes in plasma adrenomedullin (ADM) levels and how enalapril treatment affects diabetic rats over time.
- The experiment involved 52 Wistar rats divided into different groups based on diabetes induction and treatment, with blood samples taken at various months to measure ADM levels.
- Results showed that diabetic rats had higher ADM levels compared to controls, but after five months, those treated with enalapril had significantly elevated ADM levels, suggesting its potential role in diabetes progression.
Article Abstract
Objective: To observe the dynamic changes of plasma adrenomedullin (ADM) levels and the effect of enalapril intervention in diabetic rats.
Methods: Fifty-two wistar rats were grouped into 1- and 3-month groups (7 each), both including a control and a streptozotocin-induced diabetic group. The 5-month group was divided into control, diabetic and enalapril-treatment diabetic groups (8 each, the last group receiving oral enalapril treatment at the daily dose of 2 mg/kg from the first to the fifth month after diabetes induction). Blood samples were collected from the heart of the rats at the end of 1, 3 and 5 months for determination of plasma ADM concentrations radioimmunoassay.
Results: Plasma ADM levels were significantly higher in diabetic rats than in the corresponding control rats in 1- and 3-month groups. ADM levels in the diabetic rats of 5-month group were significantly decreased in comparison with that of 1- and 3-month groups. In 5-month group, plasma ADM levels of enalapril-treated diabetic rats elevated significantly in comparison with that in the control rats and the diabetic rats without enalapril treatment.
Conclusion: ADM may play an important role in the pathophysiology of diabetes.
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