AI Article Synopsis
- The study investigates the effects of prostacyclin (PGI2) and its stable analogue, 7-oxo-PGI2, on the enzyme activity related to cholesterol metabolism in rabbits that were fed a high-cholesterol diet.
- It was found that while PGI2 did not significantly lower the activity of the enzyme (ACAT) that contributes to cholesterol accumulation, 7-oxo-PGI2 significantly reduced ACAT activity in the aortic wall.
- These results suggest that 7-oxo-PGI2 may have a protective effect against atherosclerosis, highlighting the potential of these compounds in cardiovascular health.
Article Abstract
It has been supposed that prostacyclin (PGI2) and its analogues have important antiatherogenic effects. The aim of this work was to test the effect of PGI2 and 7-oxo-PGI2- (a stable analogue of PGI2) (6) treatment on the acyl CoA: cholesterol-acyltransferase (ACAT) activity in the aortic wall of rabbits. The rabbits had been previously fed with cholesterol and treated with PGI2 and 7-oxo-PGI2 intravenously. Cholesterol feeding increased ACAT activity compared to the control group which was not fed with cholesterol: 16.84 nmol/mg prot./h and 10.03 nmol/mg prot./h, respectively. PGI2 treatment of the cholesterol fed group did not cause a significant decrease, while 7-oxo-PGI2 treatment significantly decreased aortic ACAT activity compared to the cholesterol-fed control group; 14.31 nmol/mg prot./h; 11.53 nmol/mg prot./h and 16.84 nmol/mg prot./h, respectively. The decrease found in the ACAT activity after PGI2 and 7-oxo-PGI2 treatment are new data for the protective effect of these agents against atherosclerosis.
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| http://dx.doi.org/10.1016/S0940-2993(11)80197-1 | DOI Listing |
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