AI Article Synopsis
- * Cyanoesters yielded spirocyclopropanelactams, while cyanocarbonates produced either spirocyclopropane oxazolidinones or aminocyclopropylcarbinols.
- * The research highlights a brief synthesis of a naturally occurring compound, aminocyclopropanecarboxylic acid, showcasing the practicality of the introduced methodology.
Article Abstract
The Ti-mediated reaction of Grignard reagents with nitriles was investigated with sub-stoichiometric amounts of titanium isopropoxide. Cyanoesters were converted to spirocyclopropanelactams in good yields using as low as 0.05 eq of Ti(O(i)Pr)4. Under similar conditions, cyanocarbonates led to spirocyclopropane oxazolidinones and/or aminocyclopropylcarbinols. A very short synthesis of the naturally occurring aminocyclopropanecarboxylic acid illustrates the usefulness of this methodology.
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| http://dx.doi.org/10.1039/b508367b | DOI Listing |
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