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Biodegradable and biocompatible synthetic saccharide-Peptide hydrogels for three-dimensional stem cell culture.
Biomacromolecules
March 2011
Department of Chemistry, University of California, Irvine , California 92697-2025, USA.
Saccharide-peptide hydrogels have been developed in our laboratory as new synthetic extracellular matrices for regenerative medicine applications. In this work, we have expanded on our previously reported system and applied copolymerization of cysteine (Cys) and vinyl sulfone (VS)-functionalized saccharide-peptide polymers via Michael-type addition for encapsulation and 3D culture of cells. Specifically, our aims were to (1) develop a novel hydrogel platform, which could be applied for encapsulating and culturing mesenchymal stem cells (MSCs) in a 3D environment, (2) characterize the tunable properties of the hydrogel, specifically, degradation, mechanical, and gel network properties, and (3) determine the biocompatibility of the saccharide-peptide hydrogel material with MSCs.
View Article and Find Full Text PDF"Click" synthesis of nonsymmetrical bis(1,2,3-triazoles).
Org Lett
April 2010
Departamento de Química Orgánica-I, Universidad del País Vasco, Joxe Mari Korta R&D Center, Avda Tolosa-72, 20018 San Sebastián, Spain.
Unsymmetrically 1,1'-disubstituted 4,4'-bis-1H-1,2,3-triazoles 4 have been prepared from 4-ethynyl-1,2,3-triazoles 5 and azides. Following a "double-click" strategy, two complementary approaches were implemented for the preparation of the key 4-ethynyltriazole intermediates 5: (a) the stepwise Swern oxidation/Ohira-Bestman alkynylation of readily available 4-hydroxymethyl-1,2,3-triazoles 8 and (b) the stepwise cycloaddition of TMS-1,4-butadiyne 9. The method is highlighted by its compatibility with orthogonally protected and functionalized saccharide-peptide hybrids and its ability to be extended to the trisubstituted counterparts 12.
View Article and Find Full Text PDFSaccharide-peptide hybrid copolymers as biomaterials.
Angew Chem Int Ed Engl
October 2005
Department of Chemistry, University of California, Irvine, CA 92697-2025, USA.
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