Severity: Warning
Message: fopen(/var/lib/php/sessions/ci_sessionr79ui9c50qonvqqjsb84goa9uifordvh): Failed to open stream: No space left on device
Filename: drivers/Session_files_driver.php
Line Number: 177
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)
Filename: Session/Session.php
Line Number: 137
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Background: Promoter genomic DNA methylation is an important inactivation mechanism of tumor suppressor genes. This genetic-molecular pathway for cancer may separate a subset of patients with different prognoses and eventually different responses to specific therapies.
Aim: To analyze the methylation pattern of important genes related to different carcinogenic mechanisms in patients with gastric cancer (GC) and the relationship with its morphological features and biological behavior.
Material And Methods: Forty-seven fresh-frozen GC samples were selected. The methylation-specific PCR (MSP) test was used to analyze promoter methylation status for genes MLH1, CDKN2A (p16), APC, CDH1 (Cadherin E) and FHIT. Follow-up and complete morphological features were obtained for all cases.
Results: We found methylation in at least one of the genes studied in 83% of the cases. The frequencies of promoter hypermethylation of MLH1, CDKN2A, APC, CDH1 and FHIT were 31%, 43%, 46%, 80% y 62%, respectively. We found a relationship between APC methylation and good histological differentiation (p =0.03); CDH1 methylation with diffuse type by Lauren and 3 or more metastasic lymph nodes (p <0.05); FHIT, CDKN2A and CDH1 methylation and female condition (p <0.04). We also found a non-significant relationship between CDKN2A methylation and better survival (p =0.07).
Conclusions: The high frequency promoter methylation found confirms its importance in gastric carcinogenesis. The finding of alterations in the methylation pattern of genes studied and its association with prognostic factors is a helpful tool in the search for new criteria in clinical and therapeutic decision making.
Download full-text PDF |
Source |
---|
Diagn Pathol
March 2025
Department of Laboratory Medicine, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310006, China.
Background: Central nervous system (CNS) involvement in diffuse large B-cell lymphoma (DLBCL) is relatively rare, occurring at a rate of approximately 5%. Primary CNS lymphoma (CNS-DLBCL), a subtype of DLBCL, is rare clinically but highly malignant and invasive. Its atypical clinical symptoms and imaging features contribute to a high rate of misdiagnosis and a poor prognosis.
View Article and Find Full Text PDFCurr Opin Insect Sci
March 2025
University of São Paulo, Institute of Biosciences, Department of Zoology, São Paulo (SP), Brazil. Electronic address:
Insects exhibit a vast array of morphological specializations. Recent eco-evo-devo studies have provided a fresh perspective into how insect morphology can respond to the environment, both plastically and adaptively. Here, we performed a systematic literature analysis to identify biases and gaps in research on the molecular mechanisms underlying insect morphological adaptation and plasticity.
View Article and Find Full Text PDFJ Photochem Photobiol B
March 2025
Genetics and Molecular Biology Division, Zoology Department, Faculty of Science, Beni-Suef University, 62521 Beni-Suef, Egypt.
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disorder characterized by joint damage and persistent pain. Despite advances in treatment, there is currently no definitive cure for RA, and the side effects of available medications often limit their long-term use. Therefore, this study investigated the therapeutic potential of femtosecond laser irradiation (FSL) in treating arthritis induced by complete Freund's adjuvant (CFA) in a rat model.
View Article and Find Full Text PDFHead Neck Pathol
March 2025
Surgical Pathology Laboratory, Oral Pathology Department, Facultad de Odontología, Universidad de Buenos Aires, M.T. Alvear 2142. (C1122AAH), Ciudad Autónoma de, Buenos Aires, Argentina.
Aim: The aim of the present work was to analyze 20 cases of calcifying epithelial odontogenic tumour (CEOT), also known as "Pindborg tumour", and contrast the data with findings reported in the literature.
Materials And Methods: Twenty cases of CEOT filed in the archives of the Surgical Pathology Laboratory of the Oral Pathology Department, School of Dentistry, University of Buenos Aires, over a period of 63 years (1960-2023) were retrieved. Their histopathological, histochemical-immunohistochemical, and clinical-radiographic features were evaluated, and the obtained data were compared with those reported in the literature.
Head Neck Pathol
March 2025
Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, University of the Western Cape and National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa.
Background: Langerhans cell histiocytosis (LCH) rarely presents in the oral and maxillofacial region, and while isolated and small collections of Langerhans-type cells have been found in periapical cysts, there have been no reported cases of LCH arising in periapical cysts.
Methods: A 58-year-old female presented with isolated erythematous dry skin lesions and a radiolucent lesion of the anterior maxilla. Microscopic examination of the enucleation specimen revealed a periapical cyst with large collections of atypical cells with grooved folded nuclei with eosinophils consistent with LCH.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!