This research examined how implicit and self-attributed needs to achieve (labeled as n Ach and san Ach, respectively) combine with self-referenced and norm-referenced feedback to predict effort-related (task performance) and choice-related (task continuation) indexes of students' engagement in a mental concentration task. In Experiment 1 the authors found that in a task-focused setting, task performance was predicted by the joint effect of self-referenced feedback and n Ach, whereas task continuation was predicted by the joint effect of norm-referenced feedback and san Ach. In Experiment 2 the authors found that in an ego-focused setting, n Ach and san Ach interacted in the prediction of task performance but not of task continuation. In Experiment 3 the authors found that the effects of n Ach and san Ach on students' performance were mediated by the anticipated affective value of achievement outcomes. These findings are discussed in relation to a 2-system approach to achievement motivation.
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http://dx.doi.org/10.1037/0022-3514.89.2.205 | DOI Listing |
Biology (Basel)
December 2024
Laboratorio de Análisis Químico Instrumental (LAQUINS), Facultad de Ciencias Naturales y Matemáticas, Departamento de Química y Ciencias Ambientales, Escuela Superior Politécnica del Litoral, Guayaquil ECO90211, Ecuador.
The enzyme acetylcholinesterase (AChE) plays a crucial role in the termination of nerve impulses by hydrolyzing the neurotransmitter acetylcholine (ACh). The inhibition of AChE has emerged as a promising therapeutic approach for the management of neurological disorders such as Lewy body dementia and Alzheimer's disease. The potential of various compounds as AChE inhibitors was investigated.
View Article and Find Full Text PDFNat Rev Drug Discov
December 2024
INTREPID Alliance, Cambridge, MA, USA.
Biomedicines
October 2024
Department of Pharmacology and Toxicology, Veterinary School, Complutense University of Madrid, 28040 Madrid, Spain.
Am J Pathol
November 2024
LamImSys Lab, Instituto de Investigación Sanitaria Hospital 12 de Octubre, Madrid, Spain; Department of Immunology, Ophthalmology and ENT, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares, Madrid, Spain. Electronic address:
Gastrointestinal motility disturbances are a hallmark of inflammatory bowel disease (IBD); however, their mechanisms remain unclear. This study used a dextran sulfate sodium-induced colitis mouse model, deficient in mature B and T lymphocytes, to assess intestinal motility and the role of the adaptive immune system in health and IBD. In healthy mice, the absence of adaptive lymphocytes reduced acetylcholine (ACh) sensitivity in the ileum.
View Article and Find Full Text PDFLancet Microbe
November 2024
Antimicrobial Resistance Division, WHO, Geneva, Switzerland.
The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education.
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