Among the factors influencing metabolic reactions leading to inactivation of the drugs the differences resulting from properties of the specific metabolic pathways, present in various species, alterations in hepatic enzymes activity, factors influencing the degree of xenobiotics binding to proteins (albumin, lipoproteins, and alphalacid glycoprotein) should be taken into consideration. Hepatic blood flow efficiency, age, sex and diseases, hormonal regulation (mainly glucocorticosteroids and thyroid) glanol are examples of factors exerting an influence on the metabolic reactions of the organism. Important role may also be assigned to lipid-free or low protein diet.
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