[Effects of different light-dark cycles on total and differential leukocyte counts as well as spontaneous locomotor activity in mice].

Objective: To investigate the effect of different light-dark cycles on total and differential counts of leukocyte as well as spontaneous locomotor activity in mice.

Method: 144 ICR mice were raised under different light-dark cycles including LD 7 h/7 h, LD 12 h/12 h and LD 16 h/16 h for 8 weeks. Blood samples were obtained by enucleation of eye for total and differential counts of leukocyte. Another 9 mice were also divided into 3 groups and fed under same conditions as above. Their activities were recorded continuously.

Result: The change of spontaneous locomotor activity and leukocyte count were synchronized with the light-dark cycle.

Conclusion: Different light-dark cycles can influence not only the spontaneous locomotor activity, but also total and differential leukocyte counts in mice.