Objective: To evaluate the potential effect of HLF (Hawthorn leave flavonoids, w/w, 80% flavonoids) against thrombus formation, effect of HLF on hypoxia-treated human umbilical vein endothelial cell (HUVECs) was studied.
Method: The levels of cytotoxicity and NO upon HUVECs were studied by flow cytometry. Moreover, the level of calcium ion in HUVECs was examined through laser scanning confocal microscopy.
Result: Data from this study showed that HLF at concentrations of 5 micrograms/ml and 10 micrograms/ml decreased the cytotoxicity of hypoxia to HUVECs (P<0.05, P<0.01). The intracellular levels of NO and calcium ion were downregulated by HLF at concentrations of 5 micrograms/ml (P<0.01; P<0.01) and 10 micrograms/ml (vs control, P<0.01; P<0.01) too.
Conclusion: Results observed suggest that HLF protect HUVECs from hypoxia partly through its regulative effect on NO and calcium ion levels.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Bioactive Compounds and Antimicrobial Activities in Iranian Ecotypes for Potential Food and Medicinal Uses.
Food Sci Nutr
January 2025
The genus , belonging to the Rosaceae family, exhibits widespread distribution across Iran, comprising 17 species. Hawthorn has garnered significant attention in recent years as a prominent herbal remedy in phytotherapy and culinary applications. Various plant parts, including flowers, leaves, and fruits, have been traditionally employed to address cardiovascular conditions such as hypertension, hypotension, palpitations, and cardiac arrhythmias.
View Article and Find Full Text PDFGastrointestinal absorption and its regulation of hawthorn leaves flavonoids.
Sci Rep
January 2025
School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201203, P.R. China.
Hawthorn leave flavonoids (HLF) are widely used as an herb or dietary supplements for cardio-cerebrovascular diseases. However, its gastrointestinal absorption behavior and mechanism have not been disclosed. In this study, gastrointestinal absorption and its regulation of 4''-O-glucosylvitexin (GLV), 2''-O-rhamnosylvitexin (RHV), vitexin (VIT), rutin (RUT) and hyperoside (HP) in HLF were investigated using in vitro, in situ and in vivo models.
View Article and Find Full Text PDFBerries, Leaves, and Flowers of Six Hawthorn Species ( L.) as a Source of Compounds with Nutraceutical Potential.
Molecules
December 2024
Department of Food Technology and Human Nutrition, College of Natural Sciences, University of Rzeszow, 4 Zelwerowicza St., 35-601 Rzeszow, Poland.
Designing new forms of food, food additives, and nutraceuticals is necessary due to the growing needs of consumers, as well as the inflammation of civilization diseases, the prevention and treatment of which can be significantly supported by dietary intervention. For this reason, this study aimed to obtain highly bioactive preparations in the form of powders from the fruits, leaves, and flowers of six species of hawthorn ( L.) using solid phase extraction (SPE).
View Article and Find Full Text PDFBioactive compounds from Bge. leaves: potential health benefits.
Org Biomol Chem
December 2024
School of Traditional Chinese Materia Medica, Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning Province, China.
The leaves of Bge., a medicinal plant and a source of brewed tea, are often overlooked as a byproduct of fruit consumption. Despite this, these leaves have demonstrated significant cardiovascular protective and lipid-lowering properties.
View Article and Find Full Text PDFPhytochemical investigation and spectral characterization of isolated compounds from (D. Don) M. Roem (syn. Roxb) leaves: evaluation of antioxidant activity and molecular docking analysis.
Nat Prod Res
October 2024
Department of Safety Engineering, Dongguk University, Gyeongju, Gyeongbuk, South Korea.
(D. Don) M. Roem (syn.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!