AI Article Synopsis
- The study aimed to assess the potential for delivering a magnetic resonance (MR) contrast agent locally in live rabbits' kidneys using thermosensitive liposomes activated by infrared laser-induced heating.
- Utilizing advanced MR techniques, researchers effectively monitored temperature changes and confirmed that heating liposome membranes led to the localized release of the contrast agent.
- After heating, T1 relaxation time in the renal tissue decreased significantly, indicating successful contrast agent release, which could pave the way for simultaneous delivery of therapeutic agents.
Article Abstract
Purpose: To investigate the feasibility of local delivery of a magnetic resonance (MR) contrast agent in vivo using paramagnetic thermosensitive liposomes and infrared (IR) laser-induced local hyperthermia under real-time MR thermometry on rabbit kidney.
Materials And Methods: Respiratory gated, radio frequency (RF)-spoiled gradient-echo sequences were used for precise MR temperature mapping (SD = 1 degrees C). In vivo heating experiments confirmed local release of MR contrast agent from liposomes.
Results: T1 decreased from 800 msec to about 500 msec, as measured after tissue cooling, in those locations where the renal parenchyma was heated above the phase transition temperature of the liposome membrane.
Conclusion: The release of MR contrast agent has been demonstrated in rabbit kidney in vivo. This may be used as a reporter for simultaneous release of therapeutic agents.
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| http://dx.doi.org/10.1002/jmri.20416 | DOI Listing |
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