Heart, brain, and mind: a case series of multifactorial ischemic strokes in children.

Ischemic strokes in children, although generally rare events, are more prevalent than commonly believed and can adversely affect brain development. Ischemic strokes in children have been associated with various risk factors, including coagulation defects, cardiac anomalies, inborn errors of metabolism, infections, trauma, and even migraine headaches. We present four children with two or more of these risk factors, indicating multifactorial causes of strokes in children. Neuropsychologic testing in two of our cases also underscores cognitive decline as a result of recurrent strokes.