The aim of the study was to investigate safety and efficacy of spasmex (trospium chloride) in patients with idiopathic and neurogenic detrusor overactivity. The study included 66 patients with idiopathic and neurogenic detrusor overactivity. The diagnostic scheme consisted of voiding dairy for 72 hours, laboratory tests, ultrasound investigation with measurement of residual urine volume, urodynamic investigation and neurologic examination. The patients were divided into 4 groups: 15 patients with idiopathic detrusor overactivity (DOA), 16 with neurogenic DOA, 23 with combination of DOA with benign prostatic hyperplasia, 12 with overactive bladder without DOA. Initial trospium chloride dose of 15 mg/day (5 mg 3 times a day) followed by dose titration to obtain clinical efficacy was used under residual urine volume control every week. The maximal dose was 45 mg. After 12 weeks reduction of micturation frequency was registered in all the groups. Administration of small dose trospium chloride (15 mg) resulted in subjective improvement in 63 (94.5%) patients. Only 3 patients persisted with the symptoms in whom the dose was raised to 30 mg and then to 45 mg/day. Thus, spasmex demonstrated high efficacy in patients with bladder overactivity. High efficacy and safety with low cost make spasmex a drug of choice in the majority of patients with overactive bladder symptoms.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Factors responsible for dropout in the Ponseti method of clubfoot treatment: A cross-sectional study.
Qatar Med J
November 2024
Physical Therapist, Paraplegic Center Peshawar, Pakistan.
Background: The Ponseti method for clubfoot treatment is a non-surgical treatment with a successful outcome. However, many children are not able to complete Ponseti treatment due to various barriers and are termed dropout children. This study aimed to find out the factors responsible for dropout from clubfoot treatment in Peshawar, Pakistan.
View Article and Find Full Text PDFSevere Acute Transverse Myelitis With a Rapid Progression in an Infant.
Cureus
October 2024
Pediatric Intensive Care Unit, Hospital Pediátrico, Unidade Local de Saúde de Coimbra, Coimbra, PRT.
Article Synopsis
- Acute transverse myelitis (ATM) is a rare spinal cord inflammation that can result from infections or other systemic diseases, often leading to motor and sensory dysfunction.
- A case report describes a 10-month-old boy with severe ATM likely caused by enteritis, who developed rapid motor deficits and required extended care in a pediatric ICU, including mechanical ventilation.
- Despite various treatments, the patient faced prolonged recovery and significant neurological deficits, underscoring the need for comprehensive care and rehabilitation in managing severe ATM cases.
Assessing the Use of BotulinumtoxinA for Hyperactive Urinary Tract Dysfunction a Decade After Approval: General Versus Local Anesthesia for BotulinumtoxinA Detrusor Injection.
Toxins (Basel)
October 2024
Department of Urology, Charité-University Hospital Berlin, 12203 Berlin, Germany.
Article Synopsis
- OnabotulinumtoxinA detrusor injection (OnabotA DI) is a treatment for patients with overactive bladder issues that was approved 10 years ago, often performed under local anesthesia (LA) or general anesthesia (GA).
- In a study of 104 patients, those under LA reported higher anxiety and pain compared to those under GA, particularly during the first injection, but surprisingly still preferred LA despite these concerns.
- The findings highlighted a notable decrease in anxiety for repeat injections with LA, suggesting that familiarity with the procedure could ease patient anxiety over time, even though pain was significantly lower with GA.
Factors influencing the speed of correction speed of distal tibial valgus deformity in children with percutaneous epiphyseodesis using transphyseal screw.
Foot Ankle Surg
October 2024
Department of Paediatric Orthopaedics, Orthopaedische Kinderklinik, Bernauerstrasse 18, D-83229 Aschau i. Chiemgau, Bavaria, Germany.
Article Synopsis
- The study investigates distal tibial valgus deformity in children, which can resemble hindfoot valgus, and evaluates the effectiveness of a specific correction method called medial percutaneous epiphysiodesis using transphyseal screws (PETS).
- It aims to analyze correction rates based on different underlying conditions, age at treatment, severity of the deformity, and the association with other foot deformities.
- Results from a retrospective study of 104 children indicate variable correction rates, averaging 0.45° per month, influenced by age, initial deformity, and treatment duration, with a significant prevalence of associated valgus foot deformities (86.4%).
Response to Treatment with Botulinum Neurotoxin A (BoNT-A) in Children and Adolescents with Neurogenic Lower Urinary Tract Dysfunction and Idiopathic Overactive Bladder: A Systematic Review and Meta-Analysis.
Toxins (Basel)
October 2024
Urology Clinic, Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Piazzale Aristide Stefani 1, 37126 Verona, Italy.
Article Synopsis
- Botulinum neurotoxin A (BoNT-A) is being increasingly used to treat neurogenic lower urinary tract dysfunctions and overactive bladder in children and adolescents, which is a growing area in urology.
- A systematic review analyzed various studies from databases like PubMed and Scopus to evaluate BoNT-A's effectiveness in improving urinary incontinence and urodynamic parameters in this age group.
- Results showed that among 1521 patients, there was a significant improvement in urinary incontinence scores by about 75% within 3-6 months after treatment, with no major adverse effects reported.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!