Pain treatment of patients with opioid addiction and tolerance may be challenging due to their unexpectedly higher pain sensitivities and opioid requirements. It has been reported that the N-methyl-D-aspartate receptor is involved in mechanisms of tolerance to opioid analgesics. Recently enhancement of morphine induced analgesia by low dose ketamine addition to the treatment regimen has been reported. We report a cancer patient with meperidine tolerance and psychological dependency to the agent who was afterwards successfully treated with morphine-ketamine combination.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Ultrasound-guided bilateral erector spinae plane block in the management of postoperative analgesia in living liver donors: a randomized, prospective study.
Minerva Anestesiol
December 2024
Department of Anesthesiology and Reanimation, Istanbul Medipol University, Istanbul, Türkiye.
Background: Living donor hepatectomy is a procedure associated with notable postoperative pain, impacting patient recovery and satisfaction. Addressing this challenge, we aimed to examine the effect of ultrasound-guided bilateral erector spinae plane block (ESPB) in postoperative analgesia management of patients undergoing living donor hepatectomy for liver transplantation.
Methods: A single-center prospective, randomized, controlled study was conducted on ASA I-II patients aged 18-65 who underwent elective living donor hepatectomy.
Comparative efficacy of intravenous treatments for perioperative shivering in patients undergoing caesarean delivery under neuraxial anaesthesia: A systematic review and Bayesian network meta-analysis of randomised-controlled trials.
J Clin Anesth
January 2025
Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, CA, USA; Research Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK. Electronic address:
Introduction: Shivering affects 52 % of patients undergoing caesarean delivery under neuraxial anaesthesia. Despite extensive research focused on its prevention, there is still no consensus regarding optimal pharmacological treatment. This systematic review and network meta-analysis aims to compare available intravenous treatments of perioperative shivering in patients undergoing caesarean delivery under neuraxial anaesthesia.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to compare the effectiveness of two sedation combinations—midazolam/meperidine (M/M) vs. midazolam/hydromorphone (M/H)—for pediatric dental patients.
- A review of charts from healthy children aged 2 to 5 who underwent sedation treatment revealed no significant differences in treatment completion, sedation level, or overall effectiveness between the two groups.
- However, the M/H group showed better behavioral scores, suggesting that midazolam and hydromorphone could be a preferable option for moderate sedation in these patients.
Comparative study of lidocaine- saline versus saline as washout for lumpectomy cavity on acute postoperative pain.
Heliyon
October 2024
Department of Surgery, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Purpose: This study aimed to evaluate the impact of lidocaine-saline solution compared to saline alone for washing out the lumpectomy cavity, focusing on its effect on acute postoperative pain-a prevalent and significant concern among patients undergoing breast surgery.
Methods: In this comparative study, 72 patients scheduled for lumpectomy surgery were randomly assigned to either the lidocaine-saline or saline group. The lidocaine-saline group was administered a washout of the lumpectomy cavity with 2 % lidocaine at a dosage of 1.
Article Synopsis
- Shivering is a common issue during spinal anesthesia, and this review investigates the effectiveness of ketamine in preventing it, using major medical databases for research.
- Out of studies comparing ketamine to saline and tramadol, ketamine showed mixed results; some studies found it more effective while others suggested similar or better outcomes for other drugs like dexmedetomidine and meperidine.
- Ketamine appears to be a safe option for reducing shivering, especially with dosages of 0.2-0.5 mg/kg, but other medications may work just as well or better, and factors like patient type and doctor experience should guide treatment choices.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!