Haemolytic crises caused by contact with Hoya carnosa were observed in a 45-years old woman. The investigation of erythrocyte enzymes displayed both G6PD deficiency and its diminished affinity to G-6-P. Some properties of dehydrogenases isolated from erythrocytes of the patient's brother and son were also changed although clinical signs of haemolysis were absent.
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Prophylactic vs therapeutic blood transfusions impact on pregnant sickle cell patients.
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View Article and Find Full Text PDFHb Monza: A novel extensive HBB duplication with preserved α-β subunit interaction and unstable hemoglobin phenotype.
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Article Synopsis
- Sickle cell disease (SCD) is a genetic condition that leads to chronic pain and episodes called vaso-occlusive crises (VOCs), and this study investigates how certain brain chemicals are altered in patients with SCD.
- Using proton magnetic resonance spectroscopy, researchers measured levels of glutamate and glutamine (Glx) in the right posterior insula cortex of individuals with SCD and healthy controls, finding significantly higher Glx levels in SCD patients, along with notable correlations between Glx levels, VOC frequency, and pain sensitivity.
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