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Molecular and functional convergences associated with complex multicellularity in Eukarya.
Mol Biol Evol
January 2025
Laboratório de Algoritmos em Biologia, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Brazil.
A key trait of Eukarya is the independent evolution of complex multicellular (CM) in animals, plants, fungi, brown algae and red algae. This phenotype is characterized by the initial exaptation of cell-cell adhesion genes followed by the emergence of mechanisms for cell-cell communication, together with the expansion of transcription factor gene families responsible for cell and tissue identity. The number of cell types (NCT) is commonly used as a quantitative proxy for biological complexity in comparative genomics studies.
View Article and Find Full Text PDFDelirium and Cognitive Screening in National Hip Fracture Registries: Scoping Review Protocol.
HRB Open Res
January 2025
School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.
Background: Delirium and cognitive impairment are common in hip fracture populations and are associated with significant adverse patient outcomes. National hip fracture registries facilitate improvements in patient outcomes and care quality, such as reduced mortality and the development of specialist multidisciplinary services. However, there is substantial variation in the data collected and reported in relation to delirium and cognition, which impedes international comparison and may reduce quality of care.
View Article and Find Full Text PDFConfronting food insecurity through agricultural interventions: the Farmer FIRST program in India.
Front Nutr
January 2025
ICAR- National Academy of Agricultural Research Management, Hyderabad, India.
Introduction: Nutrition-sensitive agricultural interventions are crucial in addressing malnutrition and promoting food security. The Farmer, Farm, Innovation, Resources, Science, and Technology (FIRST) Program is a national-level agricultural intervention program that was started in 2016 by the Indian Council of Agricultural Research (ICAR). Its primary objective is to transform the lives and livelihoods of Indian farmers, with a focus on income and livelihood security.
View Article and Find Full Text PDFQuality of hypertension management and health insurance impact: an assessment of insured and uninsured patients with systemic hypertension in a teaching Hospital in Ilorin, Nigeria.
Malawi Med J
January 2025
Department of Epidemiology and Community Health, University of Ilorin and University of Ilorin Teaching Hospital, Nigeria.
Background: Patient satisfaction is an important indicator used to measure quality of care and the performance of healthcare services. This study assessed patient satisfaction with the quality of hypertension care received by both insured and uninsured patients with systemic hypertension.
Methods: This comparative cross-sectional study was conducted among insured and uninsured patients with systemic hypertension attending the Medical Outpatient Department clinics of the University of Ilorin Teaching Hospital, Kwara State, Nigeria, from May to July, 2023.
Protocol for Oligonucleotides Characterization Using Hydrophilic Interaction Chromatography.
J Sep Sci
January 2025
Chair of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Toruń, Poland.
Oligonucleotides (ONs) are an increasingly popular category of molecules in the pharmaceutical landscape, particularly attractive for the treatment of genetic and rare diseases. However, analyzing these molecules presents significant challenges, due to their highly hydrophilic nature, multiple negative charges, and the presence of closely related impurities resulting from the complex solid-phase synthesis process. Ion pairing reverse-phase liquid chromatography (IP-RPLC) is the preferred technique for ONs analysis but is not ideal for mass spectrometry (MS) coupling.
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