Many biological properties have been attributed to ruthenium complexes including anti-tumor activity and the attenuation of reperfusion damage and infarct size. In this work, we characterize the antioxidant activity of trans-[RuCl2(nic)4] where nic is 3-pyridinecarboxylic acid and trans-[RuCl2(i-nic)4] where i-nic is 4-pyridinecarboxylic acid by (i) evaluation of total antioxidant potential (TRAP); (ii) prevention of DNA damage induced by hydrogen peroxide using the alkaline comet assay; and (iii) the prevention of lipid peroxidation and cell death induced by iron in liver slices. Our results suggest that nic has stronger antioxidant potential when compared to the i-nic. Higher doses (above 200 microM) of these compounds gave genotoxic effects, but the antioxidant potential could be obtained with the use lower doses (0.1-10 microM).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1179/135100005X38897 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Blueberry leaves as a promising sustainable source of polyphenols: Chemical composition, functional activities and future application perspectives.
Food Res Int
April 2025
School of Food Science and Technology, Jiangnan University, Wuxi, China. Electronic address:
Blueberry leaves are a byproduct of blueberry cultivation, often overlooked despite their potential value. As global consumption of blueberries continues to rise, the area under cultivation expands, leading to an increased production of blueberry leaves. Blueberry leaves are a rich source of polyphenols, and in recent years, extensive research has been conducted on the composition and biological functions of these compounds.
View Article and Find Full Text PDFClam peptides: Preparation, flavor properties, health benefits, and safety risks.
Food Res Int
April 2025
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China; Fujian Provincial Key Laboratory of Quality Science and Processing Technology in Special Starch, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Engineering Research Center of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fuzhou, Fujian 350002, China.
Bioactive peptides derived from food proteins have attracted attention for their potential roles in functional foods and pharmaceuticals. Clams, renowned for their protein content and essential amino acids critical to human health, represent a promising source for bioactive peptide production. Recent studies have extensively explored the preparation methods, flavor profiles, and health benefits of clam peptides (CPs).
View Article and Find Full Text PDFLactic acid fermentation of a novel Sea buckthorn-monk fruit beverage: Phenolic profile, volatile compounds, and antidiabetic and antihypertensive potential.
Food Res Int
April 2025
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address:
Functional foods offer health benefits that extend beyond basic nutrition, addressing critical public health challenges such as diabetes and hypertension. This study developed a novel lactic acid bacteria (LAB)-fermented beverage integrating sea buckthorn and monk fruit, two bioactive-rich ingredients with complementary properties. Sea buckthorn provides a robust profile of antioxidants, while monk fruit's natural sweetness and low glycemic index make it an ideal ingredient for health-conscious consumers.
View Article and Find Full Text PDFDistinct responses of Caenorhabditis elegans to polyethylene microplastics and plant secondary metabolites.
Environ Pollut
March 2025
School of Environmental Science and Engineering, Tianjin University, Tianjin, 300354, China. Electronic address:
Soil worms are among the most abundant and functionally diverse soil animals. However, they have been largely overlooked in studies on microplastic (MP) toxicity. MPs and plant secondary metabolites (PSMs) are ubiquitous in soil due to plant litter decomposition and heavy MP contamination, inevitably interacting and exerting combined toxicity on soil organisms.
View Article and Find Full Text PDFDesign and Evaluation of Curcumin-Derived Aldopentose Compounds: Unlocking their Antidiabetic Potential through Integrative In Vitro, In Vivo, and In Silico Studies on Carbohydrate-Degrading Enzymes.
J Nutr Biochem
March 2025
Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:
Natural polyphenol compounds such as curcumin can inhibit carbohydrate-hydrolyzing enzymes, which may offer an alternative to expensive and potentially side-effect-inducing α-glucosidase inhibitors like acarbose. Hence, this study carried out the synthesis of curcumin aldopentose derivatives, examining their capacity to inhibit the α-glucosidase and α-amylase enzymes with the aim to alleviate hyperglycemia. Initially, the aldopentose derivatives from curcumin were synthesized and confirmed by spectroscopic methods such as MS, CNMR, HNMR, and FTIR.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!