The observed distribution of mitochondria in a cell can vary with environmental influence, degree of differentiation and disease. Differences in the distribution of mitochondrial autofluorescence may be used to distinguish these different cellular states.
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Reprogramming Macrophage Phenotypes with Photobiomodulation for Enhanced Inflammation Control in ENT Organ Tissues.
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Department of Otolaryngology-Head and Neck surgery, Dankook University School of Medicine, Cheonan, Korea.
Photobiomodulation (PBM), a noninvasive phototherapy using wavelengths ranging between red and near-infrared light, has emerged as a promising approach for controlling inflammation by modulating macrophage polarization. This review investigates the therapeutic potential of PBM in treating ear, neck, and throat (ENT)-specific inflammatory conditions, such as chronic rhinosinusitis and otitis media, focusing on its effects on macrophage phenotypes and evidence from preclinical studies. By promoting mitochondrial activity, increasing ATP production, and modulating reactive oxygen species, PBM has been shown to shift macrophages from a proinflammatory to an anti-inflammatory phenotype.
View Article and Find Full Text PDFA mitochondrial targeted fluorescent probe for imaging nitroreductase activity and photodynamic therapy in tumor cells.
Talanta
December 2024
Department of Hepato-Pancreato-Biliary Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315211, China; Health Science Center, Ningbo University, Ningbo, Zhejiang, 315211, China. Electronic address:
The hypoxic environment in tumors is closely linked to tumor structure, function, dissemination, invasion, metastasis, and drug resistance. Nitroreductase (NTR) is often recognized as a biomarker to evaluate the hypoxia degree for tumor cells. Traditional detection methods such as PET, MRI and multispectral photoacoustic tomography have limitations.
View Article and Find Full Text PDFTranscriptomic analysis of plasma-derived small extracellular vesicles reveals the pathological characteristics of normal tension glaucoma.
Extracell Vesicles Circ Nucl Acids
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State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang, China.
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Gut
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J Clin Med
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Third Department of Urology, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.
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