Objective: To evaluate the effect of positive end-expiratory pressure on the sound filtering characteristics of injured lungs.
Design And Setting: Prospective experimental study in the animal laboratory in an academic medical center.
Patients And Participants: Six 35- to 45-kg anesthetized, intubated pigs.
Interventions: Acute lung injury with intravenous oleic acid.
Measurements And Results: We injected a multifrequency broad-band sound signal into the airway while recording transmitted sound at three locations bilaterally on the chest wall. Oleic acid injections effected a severe pulmonary edema predominantly in the dependent lung regions, with an average increase in venous admixture from 16+/-14% to 57+/-13% and a reduction in static respiratory system compliance from 31+/-6 to 16+/-3 ml/cm H(2)O. A significant concomitant increase in sound transfer function amplitude was seen in the dependent and lateral lung regions; little change occurred in the nondependent areas. The application of PEEP resulted in a decrease in venous admixture, increase in respiratory system compliance, and return of the sound transmission to preinjury levels.
Conclusions: Acute lung injury causes regional acoustic transmission abnormalities that are reversed during alveolar recruitment with PEEP.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00134-005-2745-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lateral decubitus: its influence on hemodynamic and respiratory function during retroperitoneal robotic assisted laparoscopic pyeloplasty (R-RALP) in children.
J Robot Surg
January 2025
Department of Pediatric Anesthesia and Intensive Care, Necker-Enfants Malades University Hospital, AP-HP Centre, Université Paris Cité, 149, Rue de Sèvres 75015, Paris, France.
Retroperitoneal robotic-assisted laparoscopic pyeloplasty (R-RALP) is the commonest urologic procedure performed in children, entailing retroperitoneal CO2 insufflation and lateral decubitus, whose effects on cardiopulmonary variables are poorly known. We, therefore, studied hemodynamic and respiratory changes due to CO2 insufflation and lateral decubitus in children undergoing R-RALP and their effects on regional tissue oxygenation. Between 1/2021 and 7/2024, children affected by ureteropelvic joint obstruction (UPJO) underwent a pyeloplasty by R-RALP at Necker Enfants Malades Hospital (Paris, France), using a standardized surgical technique and a lung-protecting anesthetic protocol aimed to prevent hypercarbia.
View Article and Find Full Text PDFCold stimulated bronchial epithelial cells derived exosomes HMGB1 aggravates bronchial epithelial cells injury.
Mol Immunol
January 2025
Yancheng First People's Hospital Pharmacy Department, China. Electronic address:
The aim of this study was to reveal the mechanism of cold stimulation (CS)-bronchial epithelial cells (BECs) derived exosomes (CS-BECs-exo) aggravated sepsis induced acute lung injury (SALI). CS-BECs-exo were separated by differential centrifugation and were characterized. Proteomics, immunoprecipitation, and RAGE knockout (RAGE) mice were used to investigate the mechanism of CS-BECs-exo aggravated SALI.
View Article and Find Full Text PDFIntraoperative FiO and risk of impaired postoperative oxygenation in lung resection: A propensity score-weighted analysis.
J Clin Anesth
January 2025
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. Electronic address:
Study Objective: To assess whether, in a lung resection cohort with a low probability of confounding by indication, higher FiO is associated with an increased risk of impaired postoperative oxygenation - a clinical manifestation of lung injury/dysfunction.
Design: Pre-specified registry-based retrospective cohort study.
Setting: Two large academic hospitals in the United States.
Investigation of the protective effect of cilostazol on acute lung injury-mediated inflammation and in silico molecular modelling studies of inflammatory signalling pathway: a repurposing study.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Dr. Babasaheb Ambedkar Technological University, Lonere, Raigad, 402103, India.
Acute lung injury i.e. ALI and its serious form acute respiratory distress syndrome (ARDS) are incurable medical conditions associated with significant global mortality and morbidity.
View Article and Find Full Text PDFImmunohistochemical labeling of ongoing axonal degeneration 10 days following cervical contusion spinal cord injury in the rat.
Spinal Cord
January 2025
McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Study Design: Experimental Animal Study.
Objective: To continue validating an antibody which targets an epitope of neurofilament light chain (NF-L) only available during neurodegeneration and to utilize the antibody to describe the pattern of axonal degeneration 10 days post-unilateral C4 contusion in the rat.
Setting: University of Florida laboratory in Gainesville, USA.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!