Twenty-one three-year-old dobermanns with subclinical hepatitis were treated with nandrolone laurate or a placebo in a double-blind trial. The dogs were scored clinically before and after four months of treatment and they were evaluated by clinical biochemistry and liver biopsies. After the treatment no significant differences were observed between the two groups in any of the clinical biochemistry values; eight of the 21 dogs had no histological evidence of hepatitis and five other dogs had improved, but there was no significant difference between the responses of the two groups.
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http://dx.doi.org/10.1136/vr.157.11.313 | DOI Listing |
Drug Test Anal
April 2014
LUNAM Université, Oniris, Laboratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes, F-44307, France; Laboratoire des Courses Hippiques (LCH), Verrières le Buisson, F-91370, France.
Nandrolone (17β-hydroxy-4-estren-3-one) is amongst the most misused endogenous steroid hormones in entire male horses. The detection of such a substance is challenging with regard to its endogenous presence. The current international threshold level for nandrolone misuse is based on the urinary concentration ratio of 5α-estrane-3β,17α-diol (EAD) to 5(10)-estrene-3β,17α-diol (EED).
View Article and Find Full Text PDFJ Chromatogr A
April 2013
LUNAM Université, Oniris, Laboratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), Nantes F-44307, France.
During last decades, the use of natural steroids in racing and food producing animals for doping purposes has been flourishing. The endogenous or exogenous origin of these naturally occurring steroids has since remained a challenge for the different anti-doping laboratories. The administration of these substances to animals is usually made through an intra-muscular pathway with the steroid under its ester form for a higher bioavailability and a longer lasting effect.
View Article and Find Full Text PDFRapid Commun Mass Spectrom
June 2008
Unitat de Recerca en Farmacologia, Institut Municipal d'Investigació Mèdica, IMIM, Barcelona, Spain.
17beta-Nortestosterone (17betaN) is illegally used in livestock as a growth promoter and its endogenous production has been described in some animals, such as adult boars. In this paper, the metabolism of 17betaN in boars has been studied by gas chromatography/mass spectrometry (GC/MS) in order to identify markers of the exogenous administration. Administration studies of intramuscular 17betaN laurate to male pigs were performed.
View Article and Find Full Text PDFVet Rec
September 2005
Department of Clinical Sciences of Companion Animals, PO Box 80154, University of Utrecht, 3508 TD Utrecht, The Netherlands.
Twenty-one three-year-old dobermanns with subclinical hepatitis were treated with nandrolone laurate or a placebo in a double-blind trial. The dogs were scored clinically before and after four months of treatment and they were evaluated by clinical biochemistry and liver biopsies. After the treatment no significant differences were observed between the two groups in any of the clinical biochemistry values; eight of the 21 dogs had no histological evidence of hepatitis and five other dogs had improved, but there was no significant difference between the responses of the two groups.
View Article and Find Full Text PDFCardiovasc J S Afr
August 2005
Department of Medical Physiology, Faculty of Health Sciences, University of Stellenbosch, Tygerberg.
Unlabelled: Androgenic anabolic steroids (AAS) are often used by athletes to enhance athletic performance but are strongly associated with detrimental cardiovascular effects including sudden cardiac death.
Hypothesis: AAS use increases myocardial susceptibility to ischaemia/reperfusion injury.
Methods: Rats were trained (swimming) with or without intramuscular injection of nandrolone laurate (0.
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