AI Article Synopsis
- CD4+CD56+ hematodermic neoplasms (HNs) are aggressive skin cancers with poor outcomes and may originate from plasmacytoid dendritic cells (pDCs).
- A study evaluated 5 HN cases, finding all expressed CD123 and most showed BDCA-2 staining, suggesting a pDC-like profile in malignant cells.
- Additionally, MxA protein, indicating type I interferon activity, was present in 4 out of 5 cases, reinforcing the idea of a pDC origin for these neoplasms.
Article Abstract
CD4+CD56+ hematodermic neoplasms (HNs) with initial presentation in the skin are characterized by highly aggressive behavior and poor prognosis. Recent studies indicate that malignant cells, which are devoid of common T-, B-, NK-, and myeloid lineage markers, may be of plasmacytoid dendritic cell (pDC) origin. We undertook a study to assess the expression of several pDC-associated molecules on a series of 5 CD4+CD56+ HN cases. CD123 was expressed in all 5 cases, with some heterogeneity in individual cases. All but one case revealed fine membranous BDCA-2 staining of the dermal infiltrate. pDC-like phenotype of the malignant infiltrating cells was confirmed by costaining of BDCA-2+ cells with CD123 and CD4. MxA protein, representing the surrogate marker for lesional type I interferon activity, was expressed in 4 of 5 evaluated cases. Our findings further substantiate the putative pDC origin of CD4+CD56+ HNs.
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| http://dx.doi.org/10.1016/j.humpath.2005.07.002 | DOI Listing |
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