AI Article Synopsis
- Phototherapy is an effective treatment for neonatal jaundice, utilizing riboflavin and metalloporphyrins as photosensitizers to enhance bilirubin breakdown.
- A combined treatment approach using both riboflavin and metalloporphyrins was investigated to improve the effectiveness of phototherapy and reduce toxic side effects.
- While the combination treatment proved effective in reducing Heme Oxygenase activity, further research is needed to assess potential side effects of metalloporphyrins before clinical use.
Article Abstract
Phototherapy is commonly used for the treatment of neonatal jaundice. Riboflavin is a photosensitizer that generates singlet oxygen, which promotes bilirubin photodecomposition. Metalloporphyrins are also effective photosensitizers. The effect of a combined dosing regimen of riboflavin and metalloporphyrins was studied, with the aim of increasing the efficiency of the phototherapeutic treatment of hyperbilirubinemia. It was envisaged that riboflavin and the metalloporphyrins, by promoting the photodecomposition of bilirubin, would thereby lead to a reduction of the toxic side effects associated with phototherapy. The results shows that a phototherapeutic treatment, in which riboflavin and metalloporphyrins were co-administered, was effective in reducing Heme Oxygenase activity. However, a comprehensive study of the possible side effects of metalloporphyrin treatment in the wavelength under consideration is essential prior to utilizing these compounds for any clinical applications.
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| http://dx.doi.org/10.1081/bio-200066613 | DOI Listing |
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