Comparing the metabolic pathways of parasites and their hosts facilitates the identification of new drug targets.
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| http://dx.doi.org/10.1038/nbt0905-1089 | DOI Listing |
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Institute for Comparative Genomics, and Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada.
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Laboratorio de Bioquímica y Genética Molecular, Facultad de Química, Universidad Autónoma de Yucatán, Mérida, Yucatán, México.
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The autophagy-related ubiquitin-like conjugation systems, the ATG8 and ATG12 systems, are universally conserved in eukaryotes. However, the covalent bond in the ATG12 system has recently been shown to be evolutionarily lost in Apicomplexa. Here, we show that all genes associated with the ATG12 system are absent in piroplasmida, a lineage within Apicomplexa.
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