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Neo-enhancers in T-cell acute lymphoblastic Leukaemia (T-ALL) and beyond.
Int J Cancer
January 2025
Laboratory of Onco-Hematology, Necker Children's Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
T-cell acute lymphoblastic leukaemia (T-ALL) is a rare aggressive haematological malignancy characterised by the clonal expansion of immature T-cell precursors. It accounts for 15% of paediatric and 25% of adult ALL. T-ALL is associated with the overexpression of major transcription factors (TLX1/3, TAL1, HOXA) that drive specific transcriptional programmes and constitute the molecular classifying subgroups of T-ALL.
View Article and Find Full Text PDFThe Black Esophagus: A Rare Case Presentation.
Cureus
December 2024
Gastroenterology and Hepatology, Saint Peter's University Hospital, New Brunswick, USA.
Acute esophageal necrosis (AEN), also known as black esophagus or Gurvits syndrome, is an uncommon endoscopic finding characterized by diffuse, circumferential, black discoloration of the esophagus that terminates at the gastroesophageal junction. The incidence of AEN has been reported to be 0-0.2% in autopsy series and up to 0.
View Article and Find Full Text PDFCryptic KMT2A::MLLT10 Rearrangement in a Highly Aggressive Acute Myeloid Leukemia.
Int J Lab Hematol
January 2025
Hematology Service and Central Laboratory of Hematology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
An inflammatory state defines a high-risk T-lineage acute lymphoblastic leukemia subgroup.
Sci Transl Med
January 2025
Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C4, Canada.
T-lineage acute lymphoblastic leukemia (ALL) is an aggressive cancer comprising diverse subtypes that are challenging to stratify using conventional immunophenotyping. To gain insights into subset-specific therapeutic vulnerabilities, we performed an integrative multiomics analysis of bone marrow samples from newly diagnosed T cell ALL, early T cell precursor ALL, and T/myeloid mixed phenotype acute leukemia. Leveraging cellular indexing of transcriptomes and epitopes in conjunction with T cell receptor sequencing, we identified a subset of patient samples characterized by activation of inflammatory and stem gene programs.
View Article and Find Full Text PDFClinical Outcomes of Acute Pyelonephritis in Type 2 Diabetes Mellitus.
Cureus
November 2024
Nephrology, Stanley Medical College, Chennai, IND.
Background Diabetes mellitus (DM) is a prevalent predisposing factor for urinary tract infections (UTIs). Among hospitalized patients with acute pyelonephritis, UTIs are more common, severe, and associated with worse outcomes, particularly in those with type 2 DM. Pyelonephritis in DM patients is more frequently bilateral and linked to greater complications, with 90% of emphysematous pyelonephritis (EMPN) and cystitis cases occurring in diabetic individuals.
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