Objective: Lateral cephalograms from the growth archive of the Sri Lankan Cleft Lip and Palate Project were analyzed in a cohort design to study the long-term effects of lip repair on dentofacial morphology in patients with unilateral cleft lip and palate.
Methods: A total of 71 patients were recruited, including 23 adult patients with nonsyndromic unilateral cleft lip and palate without surgical repair and 48 adult patients with nonsyndromic unilateral cleft lip and palate who had lip repair, but without management of alveolus or anterior vomer. The design utilized exact matching on ethnicity and statistical control for gender and age.
Results And Conclusions: The data support the hypothesis that lip repair primarily produces a bone-bending effect on the anterior maxillary alveolus (alveolar molding), accompanied by controlled uprighting of maxillary incisors, and secondarily produces a bone-remodeling effect (bone resorption) in the base of the anterior maxillary alveolus. When analyzed by the age at lip repair and the surgeon who performed lip repair, early lip repair produced a greater bone-remodeling effect than did late lip repair, and variation in the surgeon who performed lip repair had an insignificant impact on dentofacial morphology after adjusting for covariates.
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http://dx.doi.org/10.1597/04-015.1 | DOI Listing |
Biomaterials
December 2024
Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China. Electronic address:
Owing to the excellent stability, anticancer activity and immunogenicity, peroxynitrite (ONOO) has been gained enormous interests in cancer therapy. Nevertheless, precise delivery and control release of ONOO in tumors remains a big challenge. Herein, B16F10 cancer cell membrane/liposome hybrid membrane (CM-Lip) based biomimetic nanodrug with high-efficient tumor-homing and NIR-II laser controlled ONOO boost properties was designed for melanoma treatment.
View Article and Find Full Text PDFMalays J Pathol
December 2024
Universiti Malaya, Faculty of Dentistry, Department of Oral & Maxillofacial Clinical Sciences, 50603, Kuala Lumpur, Malaysia.
The surgical ciliated cyst is a newly added entity under the cysts of the jaws in the World Health Organization (WHO) Classification of Head and Neck Tumours (2022). It is preceded by a prior surgery to the jaw many years before its diagnosis. A 53-year-old Chinese female, who had undergone cleft lip and palate repair followed by orthognathic surgery before the age of 20, was referred for management of an incidentally found cyst in the left maxilla.
View Article and Find Full Text PDFJ Craniofac Surg
October 2024
Department of Surgery, School of Medicine, College of Health Sciences, Addis Ababa University, Ethopia.
Cleft lip and palate anomalies constitute both aesthetic and functional impairments for affected individuals. While an individual with an unrepaired cleft palate may adjust somewhat to the associated feeding challenges as he or she gets older, the consequent speech impairment is amenable primarily to surgery. It is pertinent to assess how well speech function is restored in individuals with cleft after surgical repairs.
View Article and Find Full Text PDFJ Craniofac Surg
December 2024
Department of Plastic Surgery, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, China.
Objective: Bilateral cleft lip nose deformity often involves nasal alar retraction. The use of autogenous auricular cartilage for correction further aggravated nasal alar retraction caused by nasal lining defects after the operation. A novel graft was developed to address bilateral cleft lip nose deformity.
View Article and Find Full Text PDFCleft Palate Craniofac J
December 2024
Department of Plastic Surgery, National Heart Institute, East of Kailash, New Delhi, India.
A case series of early postoperative complications due to trauma following primary cleft lip repair has been presented. Out of 193 primary cleft lip repair performed over the past 4 years, 5 patients had trauma related complications, 2 had complete wound dehiscence, 2 had partial dehiscence, and 1 presented with bleeding. This is the first report on complications following trauma after cleft lip repair.
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