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Fertility in transgender and gender diverse people: systematic review of the effects of gender-affirming hormones on reproductive organs and fertility.
Hum Reprod Update
January 2025
Amsterdam UMC, Location Vrije Universiteit Amsterdam, Centre of Expertise on Gender Dysphoria, Amsterdam, The Netherlands.
Background: Transgender and gender diverse (TGD) people seek gender-affirming care at any age to manage gender identities or expressions that differ from their birth gender. Gender-affirming hormone treatment (GAHT) and gender-affirming surgery may alter reproductive function and/or anatomy, limiting future reproductive options to varying degrees, if individuals desire to either give birth or become a biological parent.
Objective And Rationale: TGD people increasingly pursue help for their reproductive questions, including fertility, fertility preservation, active desire for children, and future options.
Evaluating the Efficacy and Safety of Hepatitis E Vaccination in Reproductive-Age Women: A Systematic Review and Meta-Analysis.
Vaccines (Basel)
January 2025
Kauno Kolegija Higher Education, Faculty of Medicine, Pramones pr 20, 50468 Kaunas, Lithuania.
Background: Hepatitis E virus (HEV) infection presents a significant health risk in endemic regions, especially for pregnant women, who face higher risks of severe complications, including maternal and fetal mortality. The recombinant HEV vaccine, HEV239, has demonstrated high efficacy in the general population, yet data on its safety and efficacy in women of a childbearing age remain limited. This systematic review and meta-analysis aim to evaluate the safety and effectiveness of HEV239 in this specific population, with a focus on pregnancy-related outcomes.
View Article and Find Full Text PDFAn "Engram-Centric" Approach to Transient Global Amnesia (TGA) and Other Acute-Onset Amnesias.
Neurol Int
January 2025
Department of Brain Repair & Rehabilitation, Institute of Neurology, University College London, London WC1E 6BT, UK.
The differential diagnosis of acute-onset amnesia includes transient global amnesia (TGA), transient epileptic amnesia (TEA), and functional (or psychogenic) amnesia. The most common of these, TGA, is a rare but well-described condition characterised by a self-limited episode of dense anterograde amnesia with variable retrograde amnesia. Although the clinical phenomenology of TGA is well described, its pathogenesis is not currently understood, thus preventing the development of evidence-based therapeutic recommendations.
View Article and Find Full Text PDFSpectral Bidirectional Reflectance Distribution Function Simplification.
J Imaging
January 2025
ViGIL, Indian Institute of Technology Bombay, Mumbai 400076, India.
Non-diffuse materials (e.g., metallic inks, varnishes, and paints) are widely used in real-world applications.
View Article and Find Full Text PDFCombined Input Deep Learning Pipeline for Embryo Selection for In Vitro Fertilization Using Light Microscopic Images and Additional Features.
J Imaging
January 2025
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
The current process of embryo selection in in vitro fertilization is based on morphological criteria; embryos are manually evaluated by embryologists under subjective assessment. In this study, a deep learning-based pipeline was developed to classify the viability of embryos using combined inputs, including microscopic images of embryos and additional features, such as patient age and developed pseudo-features, including a continuous interpretation of Istanbul grading scores by predicting the embryo stage, inner cell mass, and trophectoderm. For viability prediction, convolution-based transferred learning models were employed, multiple pretrained models were compared, and image preprocessing techniques and hyperparameter optimization via Optuna were utilized.
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