Background: In this study, we investigated the inhibitory effects of desflurane and sevoflurane on oxytocin-induced contractions of isolated human myometrium.
Methods: Following delivery of the infant and placenta, a small segment of myometrium was excised from the upper incisional surface of the lower uterine segment and 20 strips, randomly assigned into two groups (n = 10), were obtained from 20 non-laboring term parturients. The study protocol consisted of a 60-min period of spontaneous contractions, control recording with oxytocin 2 x 10(9) m (10-min period), washout interval of 10 min, volatile administration (three times per 15-min period) of 0.5, 1 and 2 minimum alveolar concentration (MAC), response to oxytocin (10-min period), a further washout interval (10-min period) and subsequent control recording with oxytocin without anesthetics.
Results: After oxytocin administration, the frequency and amplitude of contractions increased (P < 0.05) and the duration decreased (P < 0.05). The frequency and amplitude of contractions induced with oxytocin decreased significantly at 0.5, 1 and 2 MAC of desflurane and sevoflurane (P < 0.05). The amplitude of contractions was significantly different at 1 MAC between the two groups (P < 0.05). The duration of contractions at 2 MAC decreased in both groups (P < 0.05).
Conclusions: Desflurane and sevoflurane at 0.5, 1 and 2 MAC inhibit the frequency and amplitude of myometrial contractions induced with oxytocin in a dose-dependent manner. However, desflurane inhibits the amplitude less than sevoflurane at 1 MAC. We suggest that 0.5 MAC of both agents and 1 MAC of desflurane may be safely used in the presence of oxytocin following delivery of the infant and placenta during Cesarean section without fear of uterine atony and hemorrhage.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1399-6576.2005.00804.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Environmental impact of commonly used anaesthetic agents: systematic literature review with narrative synthesis.
BJA Open
March 2025
Department of Anaesthesia, The William Harvey Hospital, Ashford, UK.
Background: Increasing awareness of the potential environmental impact of volatile anaesthetic agents has stimulated increased use of total i.v. anaesthesia.
View Article and Find Full Text PDFAnesthetic approaches and 2-year recurrence rates in non-muscle invasive bladder cancer: a randomized clinical trial.
Reg Anesth Pain Med
December 2024
Department of Urology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea
Background: The effect of anesthesia methods on non-muscle invasive bladder cancer (NMIBC) recurrence post-resection remains uncertain. We aimed to compare the oncological outcomes of spinal anesthesia (SA) and general anesthesia (GA) in patients with NMIBC.
Methods: This prospective randomized controlled trial recruited 287 patients with clinical NMIBC at Seoul National University Hospital from 2018 to 2020.
Anesthetic management using desflurane and nitrous oxide in a child with non-ketotic hyperglycinemia: a case report.
JA Clin Rep
December 2024
Department of Anesthesiology, Niigata University Medical and Dental Hospital, 1-754 Asahimachi-Dori, Chuo-Ku, Niigata, 951-8520, Japan.
Background: Non-ketotic hyperglycinemia (NKH) is a rare autosomal recessive disorder caused by defects in the glycine cleavage system, leading to elevated glycine levels in the central nervous system. NKH manifests in various forms, with the neonatal type being the most severe and often associated with high mortality and significant neurological impairment. This case report highlights the successful uses of desflurane and nitrous oxide for anesthetic management in a patient with NKH.
View Article and Find Full Text PDFEnvironmental impact of volatile anesthetics at a high complexity teaching hospital from 2019 to 2022: A quantitative analysis.
Rev Esp Anestesiol Reanim (Engl Ed)
December 2024
Department of Anesthesiology, Hospital Fundación Santa Fe de Bogotá, Bogotá, Colombia.
Article Synopsis
- The healthcare sector contributes significantly to greenhouse gas emissions, with inhaled anesthetics like desflurane, isoflurane, and sevoflurane being major contributors, particularly in Colombia where data has been lacking.
- A retrospective study conducted in a Bogota hospital evaluated the usage of these anesthetics from 2019 to 2022, revealing 743 kg of total anesthetics used, with desflurane being the most utilized agent.
- Results indicated a shift in usage patterns, with a 70% increase in sevoflurane and a 31% decrease in desflurane, leading to significant reductions in carbon emissions, highlighting sevoflurane's environmental benefits over desflurane in operating
Monitoring of liver and kidney profiles in anesthesiologists working in a regional reference teaching hospital in Northern Italy: analysis of health surveillance data using a linear mixed model.
Int J Occup Med Environ Health
December 2024
University of Genoa, Genoa, Italy (Department of Health Sciences (DISSAL)).
Article Synopsis
- Anesthesiologists are at risk from exposure to waste anesthetic gases, but research shows that newer gases like desflurane and sevoflurane may have better safety profiles compared to older ones like nitrous oxide.
- A study was conducted using health data from anesthesiologists and a control group of unexposed physicians in Italy from 2016 to 2022, analyzing liver and kidney function markers.
- The findings indicated no significant health differences between the two groups over time, except for a higher estimated glomerular filtrate in the exposed group, suggesting that exposure to anesthetic gases may not adversely affect liver or kidney functions.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!