The study was conducted on 56 rabbits, of White New Zealand breed, male gender. The average weight of the rabbits was 3 kg. The diabetes was evoked by intravenous injection of 10% alloxan, using the single dose of 100 mg/kg. On the 7th day after administration of alloxan, serum glucose levels were determined. The serum glucose level higher than 11.1 mmol/l was considered an indicator of the presence of diabetes. All the animals included in the study were divided into five groups: the control, 21-day diabetes, 42-day diabetes, 90-day diabetes and 180-day diabetes. Serum total cholesterol, triglycerides and high density lipoproteins levels were determined with enzymatic methods. Our studies revealed a significant increase in cholesterol and triglycerides levels. That mechanism might be responsible for faster development of atheromatosis during the course of diabetes mellitus.
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