This study was aimed at evaluating the body temperature of mice following the injection of LY 300164, an AMPA/kainate receptor antagonist, alone or in combination with carbamazepine or diphenylhydantoin. LY 300164, injected alone at the dose of 2 mg/kg, produced a potent hypothermic effect between 15 and 30 min, or 60 and 90 min, after the drug administration. The combined treatment of LY 300164 (2 mg/kg) with diphenylhydantoin (3.6 mg/kg) resulted in a significant decrease of body temperature at the time period between 0 and 30 min, whilst LY 300164 (2 mg/kg) co-administered with carbamazepine (5 mg/kg) did not affect the animal temperature. Moreover, either diphenylhydantoin (11.8 mg/kg) or carbamazepine (15.8 mg/kg) injected alone exerted the hypothermic effects elicited at times ranging between 0 and 15 min, or 60 and 90 min, after the respective drug dose administration. In conclusion, hypothermia induced by LY 300164 along with its neuroprotective effects, may be useful in various brain conditions related with neuronal loss in which hypothermia offers some profitable effects, prolonging a survival rate of neurons in the central nervous system.
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Sci Total Environ
January 2025
Ulm University, Institute of Evolutionary Ecology and Conservation Genomics, Albert-Einstein-Allee 11, 89081 Ulm, Germany. Electronic address:
Agricultural management significantly affects insects, especially pollinators, which are crucial for crop pollination and biodiversity. In agricultural landscapes, various factors spanning different spatial scales are known to affect pollinator health, which, in turn, can influence pollination services. However, the importance of these factors in driving the health and performance of different pollinator groups remains unclear.
View Article and Find Full Text PDFNat Cell Biol
January 2025
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Outer mitochondrial membrane (OMM) proteins communicate with the cytosol and other organelles, including the endoplasmic reticulum. This communication is important in thermogenic adipocytes to increase the energy expenditure that controls body temperature and weight. However, the regulatory mechanisms of OMM protein insertion are poorly understood.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
Max Planck Institute for the Physics of Complex Systems, Nöthnitzer Straße 38, 01187 Dresden, Germany.
Superdiffusion is surprisingly easily observed even in systems without the integrability underpinning this phenomenon. Indeed, the classical Heisenberg chain-one of the simplest many-body systems, and firmly believed to be nonintegrable-evinces a long-lived regime of anomalous, superdiffusive spin dynamics at finite temperature. Similarly, superdiffusion persists for long timescales, even at high temperature, for small perturbations around a related integrable model.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
European Synchrotron Radiation Facility (ESRF), 71 Avenue des Martyrs, Grenoble, CS 40220, 38043, France.
Studying the properties and phase diagram of iron at high-pressure and high-temperature conditions has relevant implications for Earth's inner structure and dynamics and the temperature of the inner core boundary (ICB) at 330 GPa. Also, a hexagonal-closed packed to body-centered cubic (bcc) phase transition has been predicted by many theoretical works but observed only in a few experiments. The recent coupling of high-power laser with advanced x-ray sources from synchrotrons allows for novel approaches to address these issues.
View Article and Find Full Text PDFSci Adv
January 2025
National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, Jiangsu 215123, China.
Flexible thermoelectric systems capable of converting human body heat or solar heat into sustainable electricity are crucial for the development of self-powered wearable electronics. However, challenges persist in maintaining a stable temperature gradient and enabling scalable fabrication for their commercialization. Herein, we present a facile approach involving the screen printing of large-scale carbon nanotube (CNT)-based thermoelectric arrays on conventional textile.
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