AI Article Synopsis
- Leukemia inhibitory factor (LIF) is a versatile glycoprotein from the IL-6 cytokine family, known for promoting growth and cell differentiation in various target cells.
- It plays a significant role in inflammatory responses by inducing acute phase protein synthesis and influencing cell recruitment to damaged areas.
- LIF also has the ability to regulate the differentiation of embryonic stem cells and other cell types, making it important in the development of several diseases.
Article Abstract
Leukemia inhibitory factor (LIF) is a pleiotropic glycoprotein belonging to the IL-6 family of cytokines. It shows a wide range of biologic activities that include the growth promotion and cell differentiation of different types of target cells, influence on bone metabolism, cachexia, neural development, embryogenesis and inflammation. LIF has potent proinflammatory property, being the inducer of the acute phase protein synthesis and affecting the cell recruitment into the area of damage or inflammation. LIF is also one of the cytokines that are capable to regulate the differentiation of embryonic stem cells, hematopoietic and neuronal cells. Due to its polyfunctional activities, LIF is involved in the pathogenic events and development of many diseases of various origin.
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