AI Article Synopsis
- b-FGF is a versatile protein that helps various cell types grow and differentiate, including skin and blood vessel cells.
- It plays a key role in processes like wound healing, tissue remodeling, and can also contribute to tumor growth and spread.
- The exact functions of b-FGF in both healthy and disease states are still not fully understood, especially in relation to inflammatory skin diseases.
Article Abstract
Basic-Fibroblast Growth Factor (b-FGF) is a multifunctional polypeptide that promotes growth and differentiation of a broad spectrum of cell types, including dermal fibroblasts, keratinocytes, endothelial cells and melanocytes. Due to its powerful mitogenic and angiogenic abilities it can influence the tissue remodeling, wound healing, neovascularization and promote tumor growth and metastases. b-FGF is also involved in some inflammatory skin diseases, but its biological role both in physiologic and pathologic conditions is not entirely recognized yet.
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