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Thyroid-stimulating hormone-secreting ectopic pituitary adenoma of the nasopharynx.
Auris Nasus Larynx
December 2014
Department of Otorhinolaryngology - Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Thyroid-stimulating hormone-secreting ectopic pituitary adenoma of the nasopharynx is highly unusual, with only three reported cases in the world literature. We describe the clinical presentation and radiologic findings in one patient with such rare lesions. A 46-year-old male with typical symptoms of Grave's disease was found to have a mass on magnetic resonance imaging.
View Article and Find Full Text PDFA phase 1 trial and pharmacokinetic study of cediranib, an orally bioavailable pan-vascular endothelial growth factor receptor inhibitor, in children and adolescents with refractory solid tumors.
J Clin Oncol
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The Children's Hospital of Philadelphia, Division of Oncology-CTRB4016, 3501 Civic Center Blvd, Philadelphia, PA 19104, USA.
Article Synopsis
- The study aimed to assess the safety, specifically the toxicity profile and maximum-tolerated dose (MTD), of the drug cediranib in children and adolescents with solid tumors.
- Sixteen patients were treated, with dose adjustments based on observed toxicities; the MTD was established at 12 mg/m²/day.
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