Low D-hormone syndrome, a disorder related to low creatinine clearance (CrCl), is associated with a roughly 4-fold increase in risk for falls. Known conditions leading to low D-hormone syndrome are CrCl < 65 ml/min, drug interactions, and chronic inflammatory diseases. This article reviews recent studies showing that treatment with D-hormone analogs, such as alfacalcidol, can reduce the frequency of falls in patients with low D-hormone syndrome.
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Evaluation of Therapies for Secondary Hyperparathyroidism Associated with Vitamin D Insufficiency in Chronic Kidney Disease.
Kidney Dis (Basel)
May 2023
OPKO Health, Miami, FL, USA.
Introduction: Parathyroid hormone-lowering responses after administration of three different therapies capable of raising serum total 25-hydroxyvitamin D (25OHD) were evaluated in patients with secondary hyperparathyroidism (SHPT), vitamin D insufficiency (VDI), and stage 3 or 4 chronic kidney disease (CKD).
Methods: Sixty-nine adult subjects with intact parathyroid hormone (iPTH) ≥85 and <500 pg/mL and VDI (25OHD <30 ng/mL) were randomized after ≥4-week washout to 2 months of open-label treatment with: (1) extended-release calcifediol (ERC) 60 μg/day; (2) immediate-release calcifediol (IRC) 266 μg/month; (3) high-dose cholecalciferol (HDC) 300,000 IU/month; or (4) paricalcitol plus low-dose cholecalciferol (PLDC) 1 or 2 μg and 800 IU/day, used as reference hormone replacement therapy. Serum 25OHD, calcium (Ca), phosphorus (P), plasma iPTH, and adverse events were monitored weekly.
Scrotal calcinosis in a patient treated with isotretinoin: a rare entity.
Acta Dermatovenerol Alp Pannonica Adriat
September 2022
Department of Urology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris Descartes University, Paris, France.
Scrotal calcinosis is a rare disorder characterized by multiple papules or nodules of calcification in the scrotal skin. The pathogenesis of this disease is poorly understood. The condition presents as several brown to yellowish asymptomatic nodules on the scrotum.
View Article and Find Full Text PDFVitamin D-Dimer: A Possible Biomolecule Modulator in Cytotoxic and Phagocytosis Processes?
Biomedicines
July 2022
Institut fuer Laborwissenschaften, 8301 Lassnitzhoehe, Austria.
Background: Vitamin D3 complexed to deglycosylated vitamin D binding protein (VitD-dgVDBP) is a water-soluble vitamin D dimeric compound (VitD-dgVDBP). It is not clear how VitD-dgVDBP affects circulating monocytes, macrophages, other immune cell systems, including phagocytosis and apoptosis, and the generation of reactive oxygen species (ROS) compared to dgVDBP. Methods: Flow cytometry was used to measure superoxide anion radical (O2*−) levels and macrophage activity in the presence of VitD-dgVDBP or dgVDBP.
View Article and Find Full Text PDFHypercalcemia in Pregnancy Due to CYP24A1 Mutations: Case Report and Review of the Literature.
Nutrients
June 2022
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.
Article Synopsis
- - Pathogenic mutations in the CYP24A1 gene lead to difficulties in breaking down vitamin D metabolites, which can cause hypercalcemia (high calcium levels) in pregnant women, especially when parathyroid hormone levels are low.
- - Diagnosis involves checking the ratio of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D, and genetic testing can confirm the presence of mutations.
- - In pregnant women with these mutations, hypercalcemia is common, but avoiding vitamin D supplements appears effective in managing the condition, as demonstrated by a case where a 24-year-old woman had hypercalcemia resolved after delivery while breastfeeding.
Potential impact of the steroid hormone, vitamin D, on the vasculature.
Am Heart J
September 2021
Department of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA; Department of Physiology, University of California, Los Angeles (UCLA), Los Angeles, CA; Department of Bioengineering, University of California, Los Angeles (UCLA), Los Angeles, CA; VA Greater Los Angeles Healthcare System, Los Angeles, Los Angeles, CA. Electronic address:
The role of vitamin D in the cardiovascular system is complex because it regulates expression of genes involved in diverse metabolic processes. Although referred to as a vitamin, it is more accurately considered a steroid hormone, because it is produced endogenously in the presence of ultraviolet light. It occurs as a series of sequentially activated forms, here referred to as vitamin D-hormones.
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