AI Article Synopsis
- Intravenous serotonin administered to narcotized rats led to a rapid decrease in local cerebral blood flow by nearly 30% and a drop in blood pressure.
- These changes in hemodynamics caused significant alterations in respiration, specifically resulting in short-term apnea in all subjects.
- The apnea observed was linked to the initial blood pressure changes and is thought to have a neurogenic origin.
Article Abstract
The effects of intravenous serotonin on respiration, cerebral circulation, and blood pressure were examined in narcotized rats. Serotonin rapidly decreased local cerebral blood flow (by almost 30%) and blood pressure. Hemodynamic phenomena were accompanied by sharp changes in the respiration pattern: short-term apnea in all cases. The mechanism of this apnea was related to initial stages in blood pressure changes and had a neurogenic nature.
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| http://dx.doi.org/10.1007/s10517-005-0213-6 | DOI Listing |
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