AI Article Synopsis
- Benz(a)pyrene administration at 20 mg/kg significantly increased the excretion of lysosomal enzymes in rat bile without harming the lysosomes.
- Constant exposure to light altered liver cell function, enhancing lysosomal activity while suppressing regular bile enzyme release.
- When benz(a)pyrene treatment was combined with light exposure, it reduced the stimulatory effects on lysosomal enzyme transport to bile but didn't completely remove the impact.
Article Abstract
Threefold administration of benz(a)pyrene in a dose of 20 mg/kg markedly stimulated biliary excretion of lysosomal enzymes from rat liver without signs of lysosomal damage. Constant light exposure induced changes attesting to functional activation of the lysosomal apparatus in liver cells and inhibited constitutive biliary excretion of lysosomal enzymes. Combined treatment decreased, but not abolished the stimulatory effect of benz(a)pyrene on vesicular transport of lysosomal enzymes to the bile.
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| http://dx.doi.org/10.1007/s10517-005-0205-6 | DOI Listing |
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