AI Article Synopsis
- TiO(2) enhances the photocatalytic degradation of mequitazine, an H(1)-blocker, under light exposure, with higher degradation rates observed when using anatase compared to rutile.
- The degradation process is significantly affected by humidity levels, demonstrating a clear correlation between water vapor pressure and the degradation rate.
- The primary degradation products from this photocatalytic process are mequitazine-S-oxide and mequitazine-sulphone, which are not produced during the typical photo-degradation of mequitazine alone.
Article Abstract
TiO(2) has been widely used in pharmaceutical products, and it also has been used as a photocatalyst. In this study, the influence of photocatalytic activity on the stability of solid-state mequitazine, an H(1)-blocker, was investigated. The photo-degradation of mequitazine with TiO(2) occurred under irradiation with both light sources. The degree of degradation of mequitazine with anatase was higher than that of rutile. The degradation was significantly enhanced with increasing relative humidity. The relationship between the apparent degradation rate constant and water vapor pressure could be clearly described by a simple power law. The major photo-degradation products of mequitazine, resulting from photocatalytic activity of TiO(2), were mequitazine-S-oxide and mequitazine-sulphone. A remarkable degradation of mequitadine occurred with addition of TiO(2), and its photocatalytic activity was controlled by water vapor pressure. The photo-degradation of mequitazine with TiO(2) is a different process from mequitazine without TiO(2), because mequitazine-S-oxide and mequitazine-sulphone are not formed with normal photo-degradation of mequitazine.
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| http://dx.doi.org/10.1248/cpb.53.1092 | DOI Listing |
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Effect of titanium dioxide on photostability of solid-state mequitazine.
Chem Pharm Bull (Tokyo)
September 2005
Formulation & Industrial Technology Lab., Taiho Pharmaceutical Co., Ltd.; Tokushima 771-0194, Japan.
Article Synopsis
- TiO(2) enhances the photocatalytic degradation of mequitazine, an H(1)-blocker, under light exposure, with higher degradation rates observed when using anatase compared to rutile.
- The degradation process is significantly affected by humidity levels, demonstrating a clear correlation between water vapor pressure and the degradation rate.
- The primary degradation products from this photocatalytic process are mequitazine-S-oxide and mequitazine-sulphone, which are not produced during the typical photo-degradation of mequitazine alone.
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